Sodium sensitivity of blood pressure in Chinese populations.
Sodium sensitivity of blood pressure in Chinese populations.
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DOI：
10.1007/s11906-009-0088-4
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发表时间：
2010-04
影响因子：
5.6
通讯作者：
Chen, Jing
中科院分区：
文献类型：
--
作者：
Chen, Jing
关键词：
临床试验表明，减少膳食钠的摄入量可以降低血压。然而，不同的个体对饮食中钠摄入量减少的反应是不同的，这种现象被称为钠敏感性。盐敏感性遗传流行病学网络（GenSalt）研究是在中国北方农村进行的一项大型家庭饮食喂养研究。这项研究表明，大约39%的中国成年人对钠敏感。钠敏感性在女性和老年人中更常见，通常血压较高。钠敏感性在对冷加压试验有较高反应的个体和代谢综合征个体中也更常见。遗传因素可能在中国人群钠敏感性中起重要作用。更好地了解钠敏感性的遗传和环境决定因素具有重要的公共卫生和临床意义。
Clinical trials have demonstrated that a reduced intake of dietary sodium lowers blood pressure. However, blood pressure reduction in response to a decrease in dietary sodium intake varies considerably among different individuals–a phenomenon described as sodium-sensitivity. The Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study was a large family-based dietary-feeding study conducted in rural north China. This study indicated that approximately 39% of Chinese adults were sodium-sensitive. Sodium-sensitivity was more common in women and in persons who were older and had higher usual blood pressure. Sodium-sensitivity was also more common in individuals with higher responses to cold pressor test and in individuals with the metabolic syndrome. Genetic factors might play an important role in determining sodium-sensitivity in the Chinese population. A better understanding of the genetic and environmental determinants of sodium-sensitivity has important public health and clinical implications.
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