Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial.
Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial.
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DOI：
10.1007/s00213-013-3322-3
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发表时间：
2014-04
影响因子：
3.4
通讯作者：
Teixeira, Antonio L.
中科院分区：
文献类型：
--
作者：
Brunoni, Andre R.;Machado-Vieira, Rodrigo;Zarate, Carlos A.;Valiengo, Leandro;Vieira, Erica L. M.;Bensenor, Isabela M.;Lotufo, Paulo A.;Gattaz, Wagner F.;Teixeira, Antonio L.
关键词：
抑郁症的炎症性假说认为，由外部和内部应激源引发的促炎细胞因子水平的增加与急性抑郁状态相关。这一假说还表明，药物治疗在一定程度上是通过抗炎作用来治疗抑郁症的。经颅直流电刺激(TDC)是一种新的、有前途的、非侵入性的躯体治疗抑郁症的方法，尽管其抗抑郁机制尚不完全清楚。在一项抗抑郁治疗试验中，我们探索了tdcs和舍曲林对免疫系统的影响。在一项为期6周的双盲安慰剂对照试验中，73名没有抗抑郁药的单相抑郁症患者被随机分为主动/假治疗组和舍曲林/安慰剂组(2×2设计)。测定血浆中几种细胞因子(IL-2、IL-4、IL-6、IL-10、IL-17a、干扰素-γ和肿瘤坏死因子-α)的水平，以探讨干预措施和临床疗效的影响。所有的细胞因子，除了肿瘤坏死因子-α，随着时间的推移而降低，这些影响在不同的干预组和在应答者和无应答者中是相似的。TDCs和舍曲林(单独和联合使用)急性抗抑郁作用可能并不特别涉及免疫系统的正常化。此外，作为第一批在抗抑郁药治疗过程中测量细胞因子的安慰剂对照试验之一，我们的研究表明，急性抑郁发作期间细胞因子水平的下降可能涉及安慰剂效应，这突显了进一步的安慰剂对照试验和观察性研究的必要性，这些试验和观察研究检查了抑郁治疗期间和急性抑郁发作缓解后细胞因子的变化。
The inflammatory hypothesis of depression states that increased levels of pro-inflammatory cytokines triggered by external and internal stressors are correlated to the acute depressive state. This hypothesis also suggests that pharmacotherapy partly acts in depression through anti-inflammatory effects. Transcranial direct current stimulation (tDCS) is a novel, promising, non-invasive somatic treatment for depression, although its antidepressant mechanisms are only partly understood. We explored the effects of tDCS and sertraline over the immune system during an antidepressant treatment trial. In a 6-week, double-blind, placebo-controlled trial, 73 antidepressant-free patients with unipolar depression were randomized to active/sham tDCS and sertraline/placebo (2×2 design). Plasma levels of several cytokines (IL-2, IL-4, IL-6, IL-10, IL-17a, IFN-γ, and TNF-α) were determined to investigate the effects of the interventions and of clinical response on them. All cytokines, except TNF-α, decreased over time, these effects being similar across the different intervention-groups and in responders vs. non-responders. tDCS and sertraline (separately and combined) acute antidepressant effects might not specifically involve normalization of the immune system. In addition, being one of the first placebo-controlled trials measuring cytokines over an antidepressant treatment course, our study showed that the decrease in cytokine levels during the acute depressive episode could involve a placebo effect, highlighting the need of further placebo-controlled trials and observational studies examining cytokine changes during depression treatment and also after remission of the acute depressive episode.
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影响因子：
168.9
作者：
Kupfer, David J.;Frank, Ellen;Phillips, Mary L.
通讯作者：
Phillips, Mary L.
影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
通讯作者：
Fregni, Felipe
影响因子：
7.6
作者：
Hannestad, Jonas;DellaGioia, Nicole;Bloch, Michael
通讯作者：
Bloch, Michael
影响因子：
9.3
作者：
Fruscella, P;Sottocorno, M;Roma, G
通讯作者：
Roma, G
影响因子：
8.2
作者：
DellaGioia, Nicole;Hannestad, Jonas
通讯作者：
Hannestad, Jonas