Cost-free lifespan extension via optimization of gene expression in adulthood aligns with the developmental theory of ageing.
Cost-free lifespan extension via optimization of gene expression in adulthood aligns with the developmental theory of ageing.
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DOI：
10.1098/rspb.2020.1728
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发表时间：
2021-02-10
期刊：
影响因子：
--
通讯作者：
Maklakov AA
中科院分区：
文献类型：
--
作者：
Lind MI;Carlsson H;Duxbury EML;Ivimey-Cook E;Maklakov AA
衰老之所以会进化，是因为随着年龄的增长，对性状的选择力会下降，但人们对衰老的近因还不完全了解。衰老的“一次性索马”理论（DST）认为，生殖和体细胞维持之间的竞争性资源分配是衰老和寿命进化的基础。相反，衰老的发展理论（DTA）认为，生物体衰老是由成年期的次优基因表达引起的。DST预测了生殖和寿命之间的权衡，DTA预测了基因表达的年龄特异性优化可以在不增加生殖成本的情况下增加寿命。在这里，我们调查了寿命，生殖，卵大小和个体健康的早期生活，成年和生殖后的RNAi敲低的五个'长寿'基因参与的关键生物过程中的秀丽隐杆线虫的发病后果。这些基因在成年期和/或生殖后期的下调增加了寿命，而我们发现生殖受损和寿命延长之间存在联系的证据有限。我们的研究结果表明，在成年期次优的基因表达往往直接导致寿命缩短，而不是通过生殖和体细胞维护之间的竞争性资源分配。因此，在调节生物体生活史的进化上保守的信号通路中，基因表达的年龄特异性优化可以增加寿命而不需要健身成本。
Ageing evolves because the force of selection on traits declines with age but the proximate causes of ageing are incompletely understood. The ‘disposable soma’ theory of ageing (DST) upholds that competitive resource allocation between reproduction and somatic maintenance underpins the evolution of ageing and lifespan. In contrast, the developmental theory of ageing (DTA) suggests that organismal senescence is caused by suboptimal gene expression in adulthood. While the DST predicts the trade-off between reproduction and lifespan, the DTA predicts that age-specific optimization of gene expression can increase lifespan without reproduction costs. Here we investigated the consequences for lifespan, reproduction, egg size and individual fitness of early-life, adulthood and post-reproductive onset of RNAi knockdown of five ‘longevity’ genes involved in key biological processes in Caenorhabditis elegans. Downregulation of these genes in adulthood and/or during post-reproductive period increases lifespan, while we found limited evidence for a link between impaired reproduction and extended lifespan. Our findings demonstrate that suboptimal gene expression in adulthood often contributes to reduced lifespan directly rather than through competitive resource allocation between reproduction and somatic maintenance. Therefore, age-specific optimization of gene expression in evolutionarily conserved signalling pathways that regulate organismal life histories can increase lifespan without fitness costs.
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影响因子：
2
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
DOI：
10.3791/61132
发表时间：
2020-05-28
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Chauve L;Le Pen J;Hodge F;Todtenhaupt P;Biggins L;Miska EA;Andrews S;Casanueva O
通讯作者：
Casanueva O
影响因子：
7.8
作者：
Hansen, Malene;Taubert, Stefan;Kenyon, Cynthia
通讯作者：
Kenyon, Cynthia
DOI：
10.1098/rstb.2010.0276
发表时间：
2011-01-12
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Kenyon C
通讯作者：
Kenyon C
影响因子：
6.6
作者：
Colchero, Fernando;Jones, Owen R.;Rebke, Maren
通讯作者：
Rebke, Maren