The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.
复制标题

DOI:
10.1098/rstb.2010.0276
复制
发表时间:
2011-01-12
期刊:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子:
--
通讯作者:
Kenyon C
Kenyon C
中科院分区:
其他
文献类型:
--
作者:
Kenyon C

文献摘要

参考文献

被引文献

相似文献

抑制胰岛素/IGF-1信号可以延长寿命,延缓动物王国中与年龄相关的疾病。这种生命延长途径是第一个被定义的,是通过对小型蛔虫秀丽隐杆线虫的遗传研究发现的。这一发现在这里描述。
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
DOI: 10.1073/pnas.79.21.6603
发表时间: 1982-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子: --
作者:
JOHNSON, TE;WOOD, WB
通讯作者: WOOD, WB
DOI: 10.1007/bf01435988
发表时间: 1993-01-01
期刊: GENETICA
影响因子: 1.5
作者:
JOHNSON, TE;TEDESCO, PM;LITHGOW, GJ
通讯作者: LITHGOW, GJ
DOI: 10.1038/nature07583
发表时间: 2009-02-05
期刊: NATURE
影响因子: 64.8
作者:
Honjoh, Sakiko;Yamamoto, Takuya;Nishida, Eisuke
通讯作者: Nishida, Eisuke
DOI: 10.1126/science.2392681
发表时间: 1990-08-24
期刊: SCIENCE
影响因子: 56.9
作者:
JOHNSON, TE
通讯作者: JOHNSON, TE
DOI: 10.1016/0092-8674(88)90131-6
发表时间: 1988-12-02
期刊: CELL
影响因子: 64.5
作者:
COSTA, M;WEIR, M;KENYON, C
通讯作者: KENYON, C