The Brucella Cell Envelope.

The Brucella Cell Envelope.
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DOI:
10.1146/annurev-micro-032521-013159
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发表时间:
2023-09-15
影响因子:
10.5
通讯作者:
--
中科院分区:
生物学1区
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--
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细胞被膜是一种多层结构,将细菌细胞内部与通常混乱的外部世界隔离开来。共同的特征定义了整个细菌王国的包膜,但细胞建立和调节这一关键屏障的分子机制是多种多样的,反映了细菌谱系的进化历史。布鲁氏菌属的细胞内病原体与更常见的革兰氏阴性菌相比,在细胞包膜结构、调节和生物发生方面表现出明显的差异,因此为革兰氏阴性菌包膜的研究提供了一个很好的比较模型。我们回顾了布鲁氏菌包膜的独特功能,强调了一个保守的调控系统,将细胞周期进程与包膜生物发生和细胞分裂联系起来。我们进一步讨论了最近发现的结构特征的布鲁氏菌包膜,确保包膜的完整性,并促进细胞生存在面对宿主免疫应激。
The cell envelope is a multilayered structure that insulates the interior of bacterial cells from an often chaotic outside world. Common features define the envelope across the bacterial kingdom, but the molecular mechanisms by which cells build and regulate this critical barrier are diverse and reflect the evolutionary histories of bacterial lineages. Intracellular pathogens of the genus Brucella exhibit marked differences in cell envelope structure, regulation, and biogenesis when compared to more commonly studied gram-negative bacteria and therefore provide an excellent comparative model for study of the gram-negative envelope. We review distinct features of the Brucella envelope, highlighting a conserved regulatory system that links cell cycle progression to envelope biogenesis and cell division. We further discuss recently discovered structural features of the Brucella envelope that ensure envelope integrity and that facilitate cell survival in the face of host immune stressors.
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