The InterPro protein families and domains database: 20 years on.

The InterPro protein families and domains database: 20 years on.
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DOI:
10.1093/nar/gkaa977
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发表时间:
2021-01-08
影响因子:
14.9
通讯作者:
Finn RD
Finn RD
中科院分区:
生物学2区
文献类型:
--
作者:
Blum M;Chang HY;Chuguransky S;Grego T;Kandasaamy S;Mitchell A;Nuka G;Paysan-Lafosse T;Qureshi M;Raj S;Richardson L;Salazar GA;Williams L;Bork P;Bridge A;Gough J;Haft DH;Letunic I;Marchler-Bauer A;Mi H;Natale DA;Necci M;Orengo CA;Pandurangan AP;Rivoire C;Sigrist CJA;Sillitoe I;Thanki N;Thomas PD;Tosatto SCE;Wu CH;Bateman A;Finn RD

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InterPro数据库(https://www.ebi.ac.uk/interpro/)提供了蛋白质序列到家族的综合分类,并鉴定了功能上重要的结构域和保守位点。InterProScan是一种基础软件,允许根据InterPro的签名搜索蛋白质和核酸序列。特征是描述蛋白质家族、结构域或位点的预测模型,由多个数据库提供。InterPro结合了代表等价家族、域或位点的签名,并提供了额外的信息,如描述、文献参考和基因本体(GO)术语,以产生一个全面的蛋白质分类资源。InterPro成立于1999年,已成为蛋白质家族注释中使用最广泛的资源之一。在此,我们报告了InterPro(81.0版)运行20年来的状况及其相关软件,包括数据库内容的更新、新网站和REST API的发布以及InterProScan的性能改进。
The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.
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影响因子: 14.9
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