Cellular modeling of cancer invasion: integration of in silico and in vitro approaches.
Cellular modeling of cancer invasion: integration of in silico and in vitro approaches.
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DOI：
10.1002/jcp.22766
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发表时间：
2012-02
影响因子：
5.6
通讯作者：
Anderson, Alexander R. A.
中科院分区：
文献类型：
--
作者：
Kam, Yoonseok;Rejniak, Katarzyna A.;Anderson, Alexander R. A.
癌症侵袭是癌症的标志之一，也是癌症转移的先决条件。然而，侵入过程非常复杂，取决于多种相关的内在和环境因素，因此很难以完全受控的方式进行实验研究。因此，对将实验室实验与多尺度计算机建模相结合的跨学科综合方法的需求不断增加。在这篇综述中，我们将总结当前适用于计算机模拟癌症侵袭的计算技术，特别关注我们实验室开发的一类基于个体细胞的模型。我们还讨论了它们与传统和新颖的体外实验的整合，包括其设计受到计算模型启发的新入侵测定。
Cancer invasion is one of the hallmarks of cancer and a prerequisite for cancer metastasis. However, the invasive process is very complex, depending on multiple correlated intrinsic and environmental factors, and thus is difficult to study experimentally in a fully controlled way. Therefore, there is an increased demand for interdisciplinary integrated approaches combining laboratory experiments with multiscale in silico modeling. In this review, we will summarize current computational techniques applicable to model cancer invasion in silico, with a special focus on a class of individual-cell-based models developed in our laboratories. We also discuss their integration with traditional and novel in vitro experimentation, including new invasion assays whose design was inspired by computational modeling.
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影响因子：
16.2
作者：
CORY, AH;OWEN, TC;CORY, JG
通讯作者：
CORY, JG
影响因子：
3.9
作者：
Aubert, M.;Badoual, M.;Grammaticos, B.
通讯作者：
Grammaticos, B.
DOI：
10.1083/jcb.119.3.493
发表时间：
1992-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gavrieli Y;Sherman Y;Ben-Sasson SA
通讯作者：
Ben-Sasson SA
影响因子：
2.2
作者：
CROUCH, SPM;KOZLOWSKI, R;FLETCHER, J
通讯作者：
FLETCHER, J
影响因子：
8.8
作者：
Enderling, H.;Hlatky, L.;Hahnfeldt, P.
通讯作者：
Hahnfeldt, P.