Inflammatory Bowel Disease and Neutrophil-Lymphocyte Ratio: A Systematic Scoping Review.
Inflammatory Bowel Disease and Neutrophil-Lymphocyte Ratio: A Systematic Scoping Review.
复制标题
炎症性肠病和中性粒细胞 - 淋巴细胞比例：系统范围审查。
DOI：
10.3390/jcm10184219
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发表时间：
2021-09-17
影响因子：
3.9
通讯作者：
Ryan JJ
中科院分区：
文献类型：
--
作者：
Langley BO;Guedry SE;Goldenberg JZ;Hanes DA;Beardsley JA;Ryan JJ
中性粒细胞-淋巴细胞比率(NLR)是全身炎症反应的生物标志物。这项系统性范围回顾的目的是检查有关NLR和炎症性肠病(IBD)的文献。系统检索PubMed、Embase、Cochrane Central、CINAHL、ClinicalTrials.gov、Cochrane Specialized Register、DOAJ、PDQT、Bisis引文索引、Scope us和Web of Science。总共有2621篇引文，产生了62项初步研究，分为四类：区分IBD患者和对照组，疾病活动差异，临床结果预测，以及NLR与其他IBD生物标记物的关联。38项研究使用受试者工作特征(ROC)曲线分析来生成最佳NLR切点，用于包括疾病活动性区分和治疗反应预测在内的应用。在最有希望的发现中，NLR可能有助于临床和内窥镜下疾病活动的鉴别以及预测对英夫利昔单抗(IFX)的反应丧失。总体而言，NLR可能是一种有前途的IBD生物标志物。考虑到IBD患者常规和连续监测的血细胞计数数据很容易计算出NLR，NLR的评估是非侵入性的、低成本的、可广泛获取的。进一步的研究有理由阐明在研究和临床实践中对NLR的评估将如何直接影响IBD患者的护理质量和成本。
Neutrophil–lymphocyte ratio (NLR) is a biomarker of the systemic inflammatory response. The objective of this systematic scoping review was to examine the literature on NLR and inflammatory bowel disease (IBD). PubMed, Embase, Cochrane CENTRAL, CINAHL, ClinicalTrials.gov, Cochrane Specialized Register, DOAJ, PDQT, Biosis Citation Index, Scopus, and Web of Science were systematically searched. A total of 2621 citations yielding 62 primary studies were synthesized under four categories: distinguishing patients with IBD from controls, disease activity differentiation, clinical outcome prediction, and association of NLR with other IBD biomarkers. Thirty-eight studies employed receiver operating characteristic (ROC) curve analysis to generate optimal NLR cutpoints for applications including disease activity differentiation and prediction of response to treatment. Among the most promising findings, NLR may have utility for clinical and endoscopic disease activity differentiation and prediction of loss of response to infliximab (IFX). Overall findings suggest NLR may be a promising IBD biomarker. Assessment of NLR is non-invasive, low cost, and widely accessible given NLR is easily calculated from blood count data routinely and serially monitored in patients with IBD. Further research is justified to elucidate how evaluation of NLR in research and clinical practice would directly impact the quality and cost of care for patients living with IBD.
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影响因子：
4.9
作者：
Bertani, Lorenzo;Rossari, Federico;Costa, Francesco
通讯作者：
Costa, Francesco
影响因子：
2.7
作者：
Beilman CL;Thanh NX;Ung V;Ma C;Wong K;Kroeker KI;Lee T;Wang H;Ohinmaa A;Jacobs P;Halloran BP;Fedorak RN
通讯作者：
Fedorak RN
影响因子：
2
作者：
Chen, Yi-Han;Wang, Li;Huang, Zhi-Ming
通讯作者：
Huang, Zhi-Ming
影响因子：
35.7
作者：
Alatab, Sudabeh;Sepanlou, Sadaf G.;Naghavi, Mohsen
通讯作者：
Naghavi, Mohsen
影响因子：
--
作者：
BARON, JH;CONNELL, AM;LENNARDJONES, JE
通讯作者：
LENNARDJONES, JE