The RNA modification landscape in human disease.
The RNA modification landscape in human disease.
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DOI：
10.1261/rna.063503.117
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Novoa EM
中科院分区：
文献类型：
--
作者：
Jonkhout N;Tran J;Smith MA;Schonrock N;Mattick JS;Novoa EM
RNA修饰历来被认为是基础结构RNA（如rRNA、tRNA和snoRNA）的微调化学结构特征。近年来，这种观点发生了巨大的变化，在很大程度上是由于系统性的努力，以全转录组的方式绘制和量化各种RNA修饰，揭示RNA修饰是可逆的，动态调节的，比最初认为的更广泛，并参与主要的生物过程，包括细胞分化，性别决定和应激反应。在这里，我们总结了知识的状态，并提供了一个目录的RNA修饰及其与神经系统疾病，癌症和其他疾病的联系。随着直接RNA测序技术的出现，我们希望这个目录将有助于优先考虑那些RNA修饰的转录组范围的地图。
RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has changed dramatically in recent years, to a large extent as a result of systematic efforts to map and quantify various RNA modifications in a transcriptome-wide manner, revealing that RNA modifications are reversible, dynamically regulated, far more widespread than originally thought, and involved in major biological processes, including cell differentiation, sex determination, and stress responses. Here we summarize the state of knowledge and provide a catalog of RNA modifications and their links to neurological disorders, cancers, and other diseases. With the advent of direct RNA-sequencing technologies, we expect that this catalog will help prioritize those RNA modifications for transcriptome-wide maps.
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