Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal.
Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal.
复制标题
无症状严重主动脉瓣狭窄的风险分层：严格评估。
DOI：
10.1093/eurheartj/ehs190
复制
发表时间：
2012
影响因子：
39.3
通讯作者：
R. Senior
中科院分区：
文献类型：
--
作者：
S. Bhattacharyya;C. Hayward;J. Pepper;R. Senior
主动脉瓣狭窄是获得性心脏瓣膜病最常见的形式之一。严重主动脉瓣狭窄患者出现症状，即晕厥、心绞痛或心力衰竭，预示着死亡的可能性很高。主动脉瓣置换术是目前的标准治疗。在真正无症状的患者中，猝死的风险被认为是低的;因此许多人主张保守治疗这些患者，直到症状出现。新出现的数据表明，某些标志物可以识别无症状患者的心脏事件高风险子集。这篇综述批判性地评价了已经确定的越来越多的不良预后标志物，并评估了这些参数如何影响临床实践，并可能确定早期手术干预的患者。
Aortic stenosis is one of the most common forms of acquired valvular heart disease. The development of symptoms, namely syncope, angina, or heart failure, in patients with severe aortic stenosis predicts a high likelihood of mortality. Aortic valve replacement is the current standard of care. In truly asymptomatic patients, the risk of sudden death is perceived to be low; therefore many advocate conservative management of these patients until symptoms develop. Emerging data suggest that certain markers may identify subsets of asymptomatic patients who are at a high risk of cardiac events. This review critically appraises the growing plethora of adverse prognostic markers that have been identified and evaluates how these parameters may influence clinical practice and potentially identify patients in whom early surgical intervention is warranted.
影响因子：
24
作者：
Mewton, Nathan;Liu, Chia Ying;Croisille, Pierre;Bluemke, David;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.