Protocol to evaluate the impact of yoga supplementation on cognitive function in schizophrenia: a randomised controlled trial.
Protocol to evaluate the impact of yoga supplementation on cognitive function in schizophrenia: a randomised controlled trial.
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DOI：
10.1017/neu.2014.9
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发表时间：
2014-10
影响因子：
3.8
通讯作者：
Deshpande, Smita Neelkanth
中科院分区：
文献类型：
--
作者：
Bhatia, Triptish;Mazumdar, Sati;Mishra, Nagendra Narayan;Gur, Raquel E.;Gur, Ruben C.;Nimgaonkar, Vishwajit Laxmikant;Deshpande, Smita Neelkanth
精神分裂症（SZ）是一种慢性疾病，治疗药物。认知功能障碍是SZ的核心特征，药物治疗相对困难。瑜伽可以改善健康人的认知功能。最近的一项开放性试验表明，瑜伽训练（YT）与常规药物治疗相结合，对SZ患者有显着的益处。描述一项正在进行的随机对照试验的方案，该试验旨在测试所报告的YT对SZ患者认知功能的有益作用是否可以复制。其次，评价YT对日常生活能力的影响。确诊的SZ患者接受常规临床治疗，并随机分配至持续性YT、持续性体育锻炼（PE）或常规治疗组（拟定共N = 234例，每组N = 78例）。试验包括每周5天的YT或PE，持续3周。参与者在6个月内接受三次评估。通过连线测验、宾夕法尼亚大学神经认知计算机成套测验测量的认知功能是主要结局指标，而通过独立生活技能调查测量的临床严重程度和日常功能是次要结局指标。截至2013年8月31日，共有309名受试者接受了随机化，超过了自然减员后拟定的294名受试者。一旦参与者开始YT或PE，他们通常会完成方案。目前还没有人员伤亡的报道。短期YT对于印度SZ患者是可行和可接受的。如果YT的有益效果被检测到，它将为SZ患者提供一种新的连续性认知补救策略。
Schizophrenia (SZ) is a chronic illness that is treated symptomatically. Cognitive dysfunction is a core feature of SZ that is relatively intractable to pharmacotherapy. Yoga can improve cognitive function among healthy individuals. A recent open trial indicated significant benefits of yoga training (YT) in conjunction with conventional pharmacotherapy among patients with SZ. To describe the protocol for an ongoing randomised controlled trial designed to test whether the reported beneficial effects of YT on cognitive function among SZ patients can be replicated. Secondarily, the effects of YT on daily functioning living skills are evaluated. Consenting patients with SZ receive routine clinical treatment and are randomised to adjunctive YT, adjunctive physical exercise (PE) or treatment as usual (proposed N = 234 total, N = 78 in each group). The trial involves YT or PE 5 days a week and lasts 3 weeks. Participants are evaluated thrice over 6 months. Cognitive functions measured by Trail Making Test, University of Pennsylvania Neurocognitive Computerised Battery were primary outcome measures while clinical severity and daily functioning measured by Independent Living Skills Survey were secondary outcome measures. A total of 309 participants have been randomised as of 31 August 2013, which exceeded beyond 294 proposed after attrition. Once participants begin YT or PE they generally complete the protocol. No injuries have been reported. Short term YT is feasible and acceptable to Indian SZ patients. If beneficial effects of YT are detected, it will provide a novel adjunctive cognitive remediation strategy for SZ patients.
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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