Adjunctive cognitive remediation for schizophrenia using yoga: an open, non-randomized trial.
Adjunctive cognitive remediation for schizophrenia using yoga: an open, non-randomized trial.
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DOI：
10.1111/j.1601-5215.2011.00587.x
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发表时间：
2012-04-01
影响因子：
3.8
通讯作者：
Deshpande SN
中科院分区：
文献类型：
--
作者：
Bhatia T;Agarwal A;Shah G;Wood J;Richard J;Gur RE;Gur RC;Nimgaonkar VL;Mazumdar S;Deshpande SN
瑜伽疗法(YT)改善了健康人的认知功能，但它对精神分裂症(SZ)患者认知功能的影响尚未被调查。辅助性YT对深圳地区认知领域损害的评估SZ患者接受YT或常规治疗(TAU，n=65，n=23)。使用计算机化的神经认知电池(CNB)评估了七个认知域的准确性和速度，从而将观察者的偏见降至最低。分别在双相I型障碍患者(n=40)、重度抑郁障碍患者(n=37)和心脏病门诊患者(n=68)中评估YT。所有患者均接受常规药物治疗。患者没有被随机分为YT或TAU。与SZ/TAU组相比，SZ/YT组在多次比较校正后，在注意力测量方面表现出显著的改善；这种变化在男性中更为突出。在其他诊断组中，小到中等效应大小的改善模式有所不同。我们的初步分析表明，通过YT等辅助治疗，精神分裂症患者的认知功能名义上有显着改善。变化的幅度因认知领域而异，也可能因诊断群体而异。
Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated. Evaluate adjunctive YT for cognitive domains impaired in SZ. Patients with SZ received YT or treatment as usual (TAU; n = 65, n = 23, respectively). Accuracy and speed for seven cognitive domains were assessed using a computerized neurocognitive battery (CNB), thus minimizing observer bias. Separately, YT was evaluated among patients with Bipolar I disorder (n = 40), Major Depressive Disorder (n = 37), and cardiology outpatients (n = 68). All patients also received routine pharmacotherapy. Patients were not randomized to YT or TAU. Compared with the SZ/TAU group, the SZ/YT group showed significantly greater improvement with regard to measures of attention following corrections for multiple comparisons; the changes were more prominent among the men. In the other diagnostic groups, differing patterns of improvements were noted with small to medium effect sizes. Our initial analyses suggest nominally significant improvement in cognitive function in schizophrenia with adjunctive therapies such as YT. The magnitude of the change varies by cognitive domain and may also vary by diagnostic group.
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