Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis.
Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis.
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DOI：
10.1155/2016/2408645
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发表时间：
2016
影响因子：
--
通讯作者：
Hua B
中科院分区：
文献类型：
--
作者：
Guo Q;Yuan Y;Jin Z;Xu T;Gao Y;Wei H;Li C;Hou W;Hua B
背景资料。血管生成拟态可以促进肿瘤的生长和转移。本文旨在进行系统的荟萃分析，探讨血管生成拟态与胃癌的临床病理及预后意义。方法：研究方法。我们检索了Pubmed、EMbase、Cochrane图书馆、中国国家知识基础设施、维普和万方数据库，以确定符合条件的研究。我们手动搜索印刷期刊和相关教科书。根据区域、论文质量、血管生成拟态鉴定方法、病理和患者数量进行亚组分析。结果。这项荟萃分析纳入了9项研究，包括997名患者。血管生成拟态阳性患者与总体生存不良(危险比=2.24，95%可信区间：1.45~3.47)、病理分级差、临床分期高、有无淋巴结转移、有无深部肿瘤侵犯和远处转移的胃癌患者显著相关。结论。血管生成拟态与中国的胃癌患者预后不良有关。世界范围内需要大样本的临床研究，未来应采用标准化方案，以更好地了解胃癌与血管生成拟态之间的关系。
Background. Vasculogenic mimicry can promote tumor growth and metastasis. This article is aimed at conducting a systematic meta-analysis to explore the clinicopathological and prognostic significance of vasculogenic mimicry and gastric cancer. Methods. We searched Pubmed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and the VIP and Wanfang Database for eligible studies. We manually searched for printed journals and relevant textbooks. Subgroups analyses were performed based on the region, manuscript quality, methods of vasculogenic mimicry identification, pathology, and number of patients. Results. Nine studies with 997 patients were included in this meta-analysis. A significant association was observed between vasculogenic mimicry-positive patients and those with gastric cancer with poor overall survival (hazard ratio = 2.24, 95% confidence interval: 1.45–3.47), poor pathological grading, high tumor node metastasis clinical stage, lymph node metastasis, deep tumor invasion, and distant metastasis. Conclusions. Vasculogenic mimicry is associated with a poor prognosis in patients with gastric cancer in China. Clinical studies with large samples are needed worldwide and standardized protocols should be adopted in the future to achieve a better understanding of the relationship between gastric cancer and vasculogenic mimicry.
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影响因子：
11.2
作者：
Schnegg CI;Yang MH;Ghosh SK;Hsu MY
通讯作者：
Hsu MY
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
血管生成拟态是喉鳞状细胞癌的关键预后因素：一种新的血液供应模式
影响因子：
6.1
作者：
Lin Peng;Wang Wei;Zhang Jin-mei
通讯作者：
Zhang Jin-mei
影响因子：
3.4
作者：
Qin, Liang;Ren, Ye;Liao, Hui
通讯作者：
Liao, Hui
OCT4 表达和血管生成拟态形成与人类乳腺癌的不良预后呈正相关
影响因子：
5.6
作者：
Liu T;Sun B;Zhao X;Li Y;Gu Q;Dong X;Liu F
通讯作者：
Liu F