Diffuse Axonal Injury: Epidemiology, Outcome and Associated Risk Factors.
Diffuse Axonal Injury: Epidemiology, Outcome and Associated Risk Factors.
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DOI：
10.3389/fneur.2016.00178
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发表时间：
2016
影响因子：
3.4
通讯作者：
de Sousa RM
中科院分区：
文献类型：
--
作者：
Vieira RC;Paiva WS;de Oliveira DV;Teixeira MJ;de Andrade AF;de Sousa RM
弥漫性轴索损伤（DAI）是一种创伤性损伤，以其严重的后果而闻名。然而，很少有研究描述DAI的结果和相关的危险因素，本研究旨在描述创伤后6个月DAI的初步诊断患者的结果，并确定在这个时间点与死亡率和依赖性相关的社会人口统计学和临床因素。在一项前瞻性队列研究中，从2013年7月至2014年2月招募了78例DAI患者。使用扩展格拉斯哥结局量表（GOS-E）在创伤性损伤后6个月内分析患者结局。平均损伤严重度评分为35.0（SD = 11.9），平均新损伤严重度评分（NISS）为46.2（SD = 15.9）。轻度DAI占44.9%，重度DAI占35.9%。创伤后6个月，30.8%的患者死亡，根据GOS-E，45.1%的患者完全康复。在logistic回归模型中，严重程度变量- DAI伴缺氧（通过外周血氧饱和度测量）和低血压（NISS值）-与患者死亡率具有统计学显著相关性;另一方面，DAI的严重程度和住院时间是依赖性的唯一显著预测因素。因此，DAI的严重程度成为死亡率和依赖性的危险因素。
Diffuse axonal injury (DAI), a type of traumatic injury, is known for its severe consequences. However, there are few studies describing the outcomes of DAI and the risk factors associated with it. This study aimed to describe the outcome for patients with a primary diagnosis of DAI 6 months after trauma and to identify sociodemographic and clinical factors associated with mortality and dependence at this time point. Seventy-eight patients with DAI were recruited from July 2013 to February 2014 in a prospective cohort study. Patient outcome was analyzed using the Extended Glasgow Outcome Scale (GOS-E) within 6 months of the traumatic injury. The mean Injury Severity Score was 35.0 (SD = 11.9), and the mean New Injury Severity Score (NISS) was 46.2 (SD = 15.9). Mild DAI was observed in 44.9% of the patients and severe DAI in 35.9%. Six months after trauma, 30.8% of the patients had died, and 45.1% had shown full recovery according to the GOS-E. In the logistic regression model, the severity variables – DAI with hypoxia, as measured by peripheral oxygen saturation, and hypotension with NISS value – had a statistically significant association with patient mortality; on the other hand, severity of DAI and length of hospital stay were the only significant predictors for dependence. Therefore, severity of DAI emerged as a risk factor for both mortality and dependence.
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影响因子：
1.9
作者：
Ljungqvist, Johan;Nilsson, Daniel;Skoglund, Thomas
通讯作者：
Skoglund, Thomas
DOI：
10.1186/1757-7241-20-12
发表时间：
2012-02-03
期刊：
Scandinavian journal of trauma, resuscitation and emergency medicine
影响因子：
--
作者：
Haddad SH;Arabi YM
通讯作者：
Arabi YM
DOI：
10.1097/00005373-197403000-00001
发表时间：
1974-01-01
影响因子：
--
作者：
BAKER, SP;ONEILL, B;LONG, WB
通讯作者：
LONG, WB
影响因子：
7.5
作者：
Lorente, Leonardo;Martin, Maria M.;Borreguero-Leon, Juan M.
通讯作者：
Borreguero-Leon, Juan M.
影响因子：
--
作者：
Manley, G;Knudson, MM;Pitts, L
通讯作者：
Pitts, L