Independent hypothalamic circuits for social and predator fear.

Independent hypothalamic circuits for social and predator fear.
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DOI:
10.1038/nn.3573
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发表时间:
2013-12
影响因子:
25
通讯作者:
Gross, Cornelius T.
Gross, Cornelius T.
中科院分区:
医学1区
文献类型:
--
作者:
Silva, Bianca A.;Mattucci, Camilla;Krzywkowski, Piotr;Murana, Emanuele;Illarionova, Anna;Grinevich, Valery;Canteras, Newton S.;Ragozzino, Davide;Gross, Cornelius T.

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The neural circuits mediating fear to naturalistic threats are poorly understood. Here we demonstrate that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region implicated in feeding, sex, and aggression, are essential for predator and social fear in mice. Our study establishes a critical role for VMH in fear and carries implications for the selective intervention in pathological fear in humans.
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