The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
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DOI：
10.1155/2017/8241953
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Tian H
中科院分区：
文献类型：
--
作者：
Yang GC;Fu BC;Zhang DY;Sun L;Chen W;Bai L;Gao T;Lu HG;Wang ZY;Kong QQ;Qiu L;Tian H
探讨SIRT3表达与非小细胞肺癌（NSCLC）患者临床指标及预后的关系。 实时荧光定量PCR检测SIRT3 mRNA水平，Western blot和免疫组化染色检测SIRT3蛋白水平。采用SPSS16.0软件进行统计学分析。 SIRT3在NSCLC组织中的表达显著高于癌旁组织。SIRT3水平与NSCLC患者的淋巴结转移和临床分期显著相关。单因素分析显示，SIRT3的表达、肿瘤大小、淋巴结转移、分化程度、临床分期与NSCLC患者的预后相关。多因素分析显示淋巴结转移、肿瘤大小和SIRT3表达是影响NSCLC患者预后的独立因素。 SIRT3与NSCLC的发生和进展相关。SIRT3的表达可作为NSCLC患者的独立预后因子，有助于判断NSCLC的预后。因此，SIRT3有可能成为NSCLC预后预测和个体化治疗的新因子。
To examine the relationship between the Sirtuin-3 (SIRT3) expression and the clinical indicators/prognosis of patients with non-small-cell lung cancer (NSCLC). The mRNA level of SIRT3 was detected by real-time PCR, while the protein level was detected by Western blot and immunohistochemical staining. SPSS 16.0 software was used for statistical analysis. The expression of SIRT3 was significantly higher in NSCLC tissue than in adjacent tissue. The SIRT3 level was correlated significantly with lymph node metastasis and clinical stage of NSCLC patients. Moreover, univariate analysis showed that the expression of SIRT3, tumor size, lymph node metastasis, degree of differentiation, and clinical stage were correlated with the prognosis of NSCLC patients. Multivariate analysis demonstrated that lymph node metastasis, the tumor size, and SIRT3 expression were independent prognostic factors for NSCLC patients. SIRT3 is associated with the development and progression of NSCLC. The SIRT3 expression can be used as an independent prognostic factor for NSCLC patients and help identify prognosis of NSCLC. Therefore, SIRT3 has the potential to become a new factor for prognosis prediction and personalized treatment of NSCLC.
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影响因子：
7.4
作者：
Bhat TA;Kumar S;Chaudhary AK;Yadav N;Chandra D
通讯作者：
Chandra D
线粒体SIRT3表达降低是与乳腺癌预后不良相关的潜在分子生物标志物。
影响因子：
3.3
作者：
Desouki MM;Doubinskaia I;Gius D;Abdulkadir SA
通讯作者：
Abdulkadir SA
影响因子：
6.2
作者：
Alhazzazi, Turki Y.;Kamarajan, Pachiyappan;Joo, Nam;Huang, Jing-Yi;Verdin, Eric;D'Silva, Nisha J.;Kapila, Yvonne L.
通讯作者：
Kapila, Yvonne L.
影响因子：
2.9
作者：
Takahashi Y;Sawada T;Akahane T;Kawase Y;Ikeda H;Makino K;Nakamura H;Hide T;Yano S;Hashimoto N;Kamada H
通讯作者：
Kamada H
DOI：
10.1007/978-1-62703-637-5_1
发表时间：
2013-01-01
期刊：
SIRTUINS: METHODS AND PROTOCOLS
影响因子：
--
作者：
Guarente, Leonard
通讯作者：
Guarente, Leonard