Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.

Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.
复制标题

丹酚酸 B 通过灭活小鼠压力过载后的 ERK1/2/GATA4 信号通路来缓解心力衰竭

DOI:
10.1371/journal.pone.0166560
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发表时间:
2016
期刊:
影响因子:
3.7
通讯作者:
Gu W
Gu W
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Yu J;Chen R;Tan Y;Wu J;Qi J;Zhang M;Gu W

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心力衰竭(HF)是一种影响数百万患者的危险疾病。丹参在中国临床上被广泛用于治疗心脏病。丹参素B(Salvioleacid B,SalB)是丹参的主要活性成分。本研究在实验性HF小鼠模型中研究了SalB对HF的作用机制和效果。方法:采用腹主动脉缩窄术(TAC)诱导压力超负荷性心力衰竭小鼠模型,分别设假手术组(10只)、TAC组(9只)、TAC+MET组(美托洛尔,阳性药物治疗,n = 9)和TAC+SalB组(SalB,240 mg·kg-1·d-1,n = 9)。应用超声心动图评价在体心脏结构和功能的动态变化。ELISA法检测血浆脑钠肽(BNP)浓度。另外,培养H9 C2大鼠心肌细胞,Western blot检测ERK 1/2、AKT磷酸化及GATA 4蛋白表达。SalB可显著抑制ERK 1/2的Thr 202/Tyr 204位点的磷酸化,但对AKT的Ser 473位点的磷酸化无明显影响,随后抑制GATA 4蛋白表达和血浆BNP(P < 0.001),并在术后2周抑制HF。我们的数据提供了一个机制,失活ERK 1/2/GATA 4信号通路SalB抑制TAC诱导的HF。
Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic acid B(SalB) is the major active component of Radix Salvia. This study investigated the mechanisms of action and effects of SalB on HF in an experimental mouse model of HF. We created a mouse model of HF by inducing pressure overload with transverse aortic constriction(TAC) surgery for 2 weeks and compared among 4 study groups: SHAM group (n = 10), TAC group (n = 9), TAC+MET group (metprolol, positive drug treatment, n = 9) and TAC+SalB group (SalB, 240 mg•kg-1•day-1, n = 9). Echocardiography was used to evaluate the dynamic changes in cardiac structure and function in vivo. Plasma brain natriuretic peptide (BNP) concentration was detected by Elisa method. In addition, H9C2 rat cardiomyocytes were cultured and Western blot were implemented to evaluate the phosphorylation of ERK1/2, AKT, and protein expression of GATA4. SalB significantly inhibited the phosphorylation of Thr202/Tyr204 sites of ERK1/2, but not Ser473 site of AKT, subsequently inhibited protein expression of GATA4 and plasma BNP(P < 0.001), and then inhibited HF at 2 weeks after TAC surgery. Our data provide a mechanism of inactivating the ERK1/2/GATA4 signaling pathway for SalB inhibition of the TAC-induced HF.
DOI: 10.1038/nrcardio.2010.165
发表时间: 2011-01
影响因子: 49.6
作者:
Bui, Anh L.;Horwich, Tamara B.;Fonarow, Gregg C.
通讯作者: Fonarow, Gregg C.
DOI: 10.1016/s0140-6736(14)61682-2
发表时间: 2015-01-10
期刊: LANCET
影响因子: 168.9
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Naghavi, Mohsen;Wang, Haidong;Lozano, Rafael;Davis, Adrian;Liang, Xiaofeng;Zhou, Maigeng;Vollset, Stein Emil;Ozgoren, Ayse Abbasoglu;Abdalla, Safa;Abd-Allah, Foad;Aziz, Muna I. Abdel;Abera, Semaw Ferede;Aboyans, Victor;Abraham, Biju;Abraham, Jerry P.;Abuabara, Katrina E.;Abubakar, Ibrahim;Abu-Raddad, Laith J.;Abu-Rmeileh, Niveen M. E.;Achoki, Tom;Adelekan, Ademola;Ademi, Zanfi Na;Adofo, Koranteng;Adou, Arsene Kouablan;Adsuar, Jose C.;Arnlov, Johan;Agardh, Emilie Elisabet;Akena, Dickens;Al Khabouri, Mazin J.;Alasfoor, Deena;Albittar, Mohammed;Alegretti, Miguel Angel;Aleman, Alicia V.;Alemu, Zewdie Aderaw;Alfonso-Cristancho, Rafael;Alhabib, Samia;Ali, Mohammed K.;Ali, Raghib;Alla, Francois;Al Lami, Faris;Allebeck, Peter;AlMazroa, Mohammad A.;Salman, Rustam Al-Shahi;Alsharif, Ubai;Alvarez, Elena;Alviz-Guzman, Nelson;Amankwaa, Adansi A.;Amare, Azmeraw T.;Ameli, Omid;Amini, Hassan;Ammar, Walid;Anderson, H. Ross;Anderson, Benjamin O.;Antonio, Carl Abelardo T.;Anwari, Palwasha;Apfel, Henry;Cunningham, Solveig Argeseanu;Arsenijevic, Valentina S. Arsic;Al Artaman;Asad, Majed Masoud;Asghar, Rana J.;Assadi, Reza;Atkins, Lydia S.;Atkinson, Charles;Badawi, Alaa;Bahit, Maria C.;Bakfalouni, Talal;Balakrishnan, Kalpana;Balalla, Shivanthi;Banerjee, Amitava;Barber, Ryan M.;Barker-Collo, Suzanne L.;Barquera, Simon;Barregard, Lars;Barrero, Lope H.;Barrientos-Gutierrez, Tonatiuh;Basu, Arindam;Basu, Sanjay;Basulaiman, Mohammed Omar;Beardsley, Justin;Bedi, Neeraj;Beghi, Ettore;Bekele, Tolesa;Bell, Michelle L.;Benjet, Corina;Bennett, Derrick A.;Bensenor, Isabela M.;Benzian, Habib;Bertozzi-Villa, Amelia;Beyene, Tariku Jibat;Bhala, Neeraj;Bhalla, Ashish;Bhutta, Zulfiqar A.;Bikbov, Boris;Bin Abdulhak, Aref;Biryukov, Stan;Blore, Jed D.;Blyth, Fiona M.;Bohensky, Megan A.;Borges, Guilherme;Bose, Dipan;Boufous, Soufiane;Bourne, Rupert R.;Boyers, Lindsay N.;Brainin, Michael;Brauer, Michael;Brayne, Carol E. G.;Brazinova, Alexandra;Breitborde, Nicholas;Brenner, Hermann;Briggs, Adam D. M.;Brown, Jonathan C.;Brugha, Traolach S.;Buckle, Geoffrey C.;Bui, Linh Ngoc;Bukhman, Gene;Burch, Michael;Nonato, Ismael Ricardo Campos;Carabin, Helesne;Cardenas, Rosario;Carapetis, Jonathan;Carpenter, David O.;Caso, Valeria;Castaneda-Orjuela, Carlos A.;Castro, Ruben Estanislao;Catala-Lopez, Ferrn;Cavalleri, Fiorella;Chang, Jung-Chen;Charlson, Fiona C.;Che, Xuan;Chen, Honglei;Chen, Yingyao;Chen, Jian Sheng;Chen, Zhengming;Chiang, Peggy Pei-Chia;Chimed-Ochir, Odgerel;Chowdhury, Rajiv;Christensen, Hanne;Christophi, Costas A.;Chuang, Ting-Wu;Chugh, Sumeet S.;Cirillo, Massimo;Coates, Matthew M.;Coffeng, Luc Edgar;Coggeshall, Megan S.;Cohen, Aaron;Colistro, Valentina;Colquhoun, Samantha M.;Colomar, Mercedes;Cooper, Leslie Trumbull;Cooper, Cyrus;Coppola, Luis M.;Cortinovis, Monica;Courville, Karen;Cowie, Benjamin C.;Criqui, Michael H.;Crump, John A.;Cuevas-Nasu, Lucia;Leite, Iuri da Costa;Dabhadkar, Kaustubh C.;Dandona, Lalit;Dandona, Rakhi;Dansereau, Emily;Dargan, Paul I.;Dayama, Anand;De la Cruz-Gongora, Vanessa;de la Vega, Shelley F.;De Leo, Diego;Degenhardt, Louisa;del Pozo-Cruz, Borja;Dellavalle, Robert P.;Deribe, Kebede;Jarlais, Don C. 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通讯作者: Murray, Christopher J. L.
DOI: 10.1093/emboj/19.23.6341
发表时间: 2000-12-01
期刊: EMBO JOURNAL
影响因子: 11.4
作者:
Bueno, OF;De Windt, LJ;Molkentin, JD
通讯作者: Molkentin, JD
DOI: 10.1016/j.bbrc.2015.10.127
发表时间: 2015-12-04
影响因子: 3.1
作者:
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通讯作者: Ma, Enlong
DOI: 10.1016/j.bcp.2014.04.008
发表时间: 2014-07-01
影响因子: 5.8
作者:
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