Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: in vitro and in vivo.
Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: in vitro and in vivo.
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DOI：
10.1016/j.canlet.2013.12.020
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发表时间：
2014-04-28
期刊：
影响因子：
9.7
通讯作者：
Cheng, Zhen
中科院分区：
文献类型：
--
作者：
Hu, Xiang;Liu, Yang;Qin, Chunxia;Pan, Zhenyu;Luo, Jun;Yu, Aixi;Cheng, Zhen
关于野生型IDH1在肿瘤发生发展中的作用的研究很少。以前，我们报道IDH1与骨肉瘤的病理分级和转移潜能呈负相关。IDH1在骨肉瘤组织中的表达低于癌旁正常骨组织。此外，我们观察了体外抗增殖和促凋亡作用的上调IDH1对骨肉瘤细胞株。IDH1的上调也显著降低了细胞的迁移和侵袭活性。出乎意料的是，IDH1的上调也抑制了体内肿瘤的生长和转移。因此，IDH 1可能代表一种潜在的新的治疗和预防骨肉瘤的策略。
Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In addition, we observed in vitro anti-proliferation and pro-apoptosis effects of up-regulated IDH1 on osteosarcoma cell lines. The migration and invasion activity was also markedly reduced by IDH1 up-regulation. Unexpectedly, IDH1 up-regulation also suppressed tumor growth and metastasis in vivo. Therefore, IDH1 may represent a potential novel treatment and preventive strategy for osteosarcoma.
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影响因子：
6.2
作者：
Kurokouchi, K;Kambe, F;Seo, H
通讯作者：
Seo, H
影响因子：
9.7
作者：
Kido, A;Tsutsumi, M;Konishi, Y
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Konishi, Y
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5.7
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Wang, Rui;Dong, Ke;Zhang, Hui-Zhong
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Zhang, Hui-Zhong
影响因子：
6.5
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Shechter, I;Dai, PH;Guan, GM
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10.7
作者：
Nekrutenko, A;Hillis, DM;Baker, RJ
通讯作者：
Baker, RJ