Revisiting the Plasmodium sporozoite inoculum and elucidating the efficiency with which malaria parasites progress through the mosquito.
Revisiting the Plasmodium sporozoite inoculum and elucidating the efficiency with which malaria parasites progress through the mosquito.
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DOI：
10.1038/s41467-024-44962-4
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发表时间：
2024-01-25
影响因子：
16.6
通讯作者：
Sinnis, Photini
中科院分区：
文献类型：
--
作者：
Kanatani, Sachie;Stiffler, Deborah;Bousema, Teun;Yenokyan, Gayane;Sinnis, Photini
当受感染的按蚊在寻找血液时携带子孢子时，疟疾就开始了。据认为，所有受感染的蚊子在其感染潜力方面是等同的，寄生虫负担在传播成功方面没有作用。在这项研究中，使用蚊子窝藏在现场观察到的唾液腺子孢子负载的整个范围内，我们证明了一个强大的和高度显着的相关性蚊子寄生虫负担和接种量。然后，我们将接种物数据与卵囊计数联系起来，卵囊计数是实地评估蚊子感染的最常用指标，并确定卵囊子孢子进入蚊子唾液腺的效率。综上所述，我们的数据支持这样的结论，即寄生虫负担较高的蚊子更有可能引发感染并有助于继续传播。总的来说，这些数据可以解释传播中一些无法解释的异质性，并为传播阻断干预提供更精确的基准。使用独特的单蚊数据，作者重新审视了疟原虫寄生虫在其载体宿主中的连续阶段之间的核心定量关系。他们的发现证明了蚊子寄生虫负担在成功传播中的重要性。
Malaria is initiated when infected anopheline mosquitoes inoculate sporozoites as they probe for blood. It is thought that all infected mosquitoes are equivalent in terms of their infectious potential, with parasite burden having no role in transmission success. In this study, using mosquitoes harboring the entire range of salivary gland sporozoite loads observed in the field, we demonstrate a strong and highly significant correlation between mosquito parasite burden and inoculum size. We then link the inoculum data to oocyst counts, the most commonly-used metric to assess mosquito infection in the field, and determine the efficiency with which oocyst sporozoites enter mosquito salivary glands. Taken together our data support the conclusion that mosquitoes with higher parasite burdens are more likely to initiate infection and contribute to onward transmission. Overall these data may account for some of the unexplained heterogeneity in transmission and enable more precise benchmarks for transmission-blocking interventions. Using unique single mosquito data the authors revisit the core quantitative relationships between sequential stages of Plasmodium parasites in their vector host. Their findings demonstrate the importance of mosquito parasite burden in onward transmission success.
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影响因子：
56.9
作者：
KHUSMITH, S;CHAROENVIT, Y;HOFFMAN, SL
通讯作者：
HOFFMAN, SL
DOI：
10.1016/0035-9203(90)90258-g
发表时间：
1990-03-01
影响因子：
2.2
作者：
ROSENBERG, R;WIRTZ, RA;BURGE, R
通讯作者：
BURGE, R
影响因子：
3.1
作者：
Medica, DL;Sinnis, P
通讯作者：
Sinnis, P
影响因子：
4
作者：
Bompard, Anais;Da, Dari F.;Cohuet, Anna
通讯作者：
Cohuet, Anna
DOI：
10.1016/0035-9203(91)90012-n
发表时间：
1991-03-01
影响因子：
2.2
作者：
PONNUDURAI, T;LENSEN, AHW;MEUWISSEN, JHET
通讯作者：
MEUWISSEN, JHET