Increase in [11C]vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids
Increase in [11C]vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids
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用合成代谢雄激素类固醇治疗的大鼠下丘脑中 [11C]vorozole 与芳香酶的结合增加
DOI：
10.1097/wnr.0b013e328010ff14
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发表时间：
2007
期刊：
影响因子：
1.7
通讯作者：
M. Bergström
中科院分区：
文献类型：
--
作者：
Kayo Takahashi;M. Hallberg;K. Magnusson;F. Nyberg;Yasuyoshi Watanabe;B. Långström;M. Bergström
在本研究中，我们研究了合成代谢雄激素治疗雄性大鼠脑中芳香化酶表达的变化。大鼠给予癸酸诺龙（15 mg/kg/天）14天，大脑用于放射自显影与[11 C]伏罗唑，这已被开发为芳香化酶的正电子发射断层扫描示踪剂。结果表明，在终纹床核和视前区的合成代谢雄激素类固醇的[11 C]伏罗唑结合显着增加。相反，在内侧杏仁核中未观察到[11 C]伏罗唑结合的显著变化。我们的研究结果表明，芳香化酶是显着上调床核的终纹和视前区的合成代谢雄激素类固醇，也表明雄激素调节芳香化酶不同的这些结构相比，内侧杏仁核。
In the present study, we investigated the alteration of aromatase expression in the brain by anabolic androgenic steroid treatment in male rats. The rats were given nandrolone decanoate (15 mg/kg/day) for 14 days, and the brains were used for autoradiography with [11C]vorozole, which has been developed as a positron emission tomography tracer for aromatase by our group. The results indicated a significant increase of [11C]vorozole binding by anabolic androgenic steroids in the bed nucleus of the stria terminalis and preoptic area. In contrast, no significant change of [11C]vorozole binding was observed in the medial amygdala. Our results suggest that aromatase is significantly upregulated in the bed nucleus of the stria terminalis and preoptic area by anabolic androgenic steroids and also suggest that androgens regulate aromatase differently in these structures compared with the medial amygdala.
影响因子：
4.8
作者：
ROSELLI, CE;HORTON, LE;RESKO, JA
通讯作者：
RESKO, JA
雄激素调节大鼠脑中芳香酶细胞色素 P450 信使核糖核酸。
影响因子：
4.8
作者：
Abdelgadir,SE;Resko,JA;Ojeda,SR;Lephart,ED;McPhaul,MJ;Roselli,CE
通讯作者：
Roselli,CE