Overcoming insecticide resistance in Anopheles mosquitoes by using faster-acting solid forms of deltamethrin.
Overcoming insecticide resistance in Anopheles mosquitoes by using faster-acting solid forms of deltamethrin.
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DOI：
10.1186/s12936-023-04554-x
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发表时间：
2023-04-21
期刊：
影响因子：
3
通讯作者：
Lees, Rosemary Susan
中科院分区：
文献类型：
--
作者：
Carson, Jessica;Erriah, Bryan;Herodotou, Stephania;Shtukenberg, Alexander G.;Smith, Leilani;Ryazanskaya, Svetlana;Ward, Michael D.;Kahr, Bart;Lees, Rosemary Susan
由于病媒种群普遍存在抗药性，用拟除虫菊酯杀虫剂控制传播疟疾的按蚊正变得越来越具有挑战性。然而，开发新的杀虫剂和杀虫剂制剂既费时又费钱。通过加热商业结晶形式制备的溴氰菊酯的活性更高的结晶形式，先前报告对易感的北美四斑按蚊的作用快12倍。在此，热活化溴氰菊酯分散在白垩，以克服各种抗性机制之间的五个西非按蚊菌株的潜力进行了研究，并评价其长期持续的致死性。通过加热购买的材料，在含有溴氰菊酯的市售粉尘中生成活性更高的溴氰菊酯形式。进行了跗部接触生物测定，以研究与市售形式的溴氰菊酯粉尘相比，其对耐药按蚊种群的有效性、效力和作用速度。在所有情况下，加热D-栅栏粉尘以产生更具活性的溴氰菊酯形式比市售制剂有效得多。班福拉M和基苏穆种群在暴露后10分钟100%被击倒，之后没有恢复。Gaoua-ara和Tiefora菌株在15分钟内表现出100%敲低，VK 7 2014菌株在20分钟内表现出100%敲低。在所有情况下，暴露后24小时观察到100%死亡率。相反，市售制剂（未加热）导致VK 7 2014、班福拉和Gaoua-ara种群在24小时内的死亡率低于4%，Tiefora和基苏穆蚊子在24小时内的死亡率分别为14%和47%。热活化粉尘在加热后13个月保持相当的功效。商业溴氰菊酯D-Fense Dust的热活化形式优于购买的材料，显著增加了对所有测试的拟除虫菊酯抗性菌株的有效性。在实验室环境条件下储存13个月后，致死率保持增加。可采用更高能量形式的常用杀虫剂，通过从其各自的固体表面更快速地吸收杀虫剂分子来克服在非洲按蚊中看到的各种抗性机制。也就是说，可以用具有抗性的杀虫剂杀死具有抗性的蚊子，而不改变杀虫剂的分子组成。
Controlling malaria-transmitting Anopheles mosquitoes with pyrethroid insecticides is becoming increasingly challenging because of widespread resistance amongst vector populations. The development of new insecticides and insecticidal formulations is time consuming and costly, however. A more active crystalline form of deltamethrin, prepared by heating the commercial crystalline form, previously was reported to be 12-times faster acting against susceptible North American Anopheles quadrimaculatus mosquitoes. Herein the potential for heat-activated deltamethrin dispersed on chalk to overcome various resistance mechanisms amongst five West African Anopheles strains is investigated, and its long-term sustained lethality evaluated. The more active deltamethrin form was generated in a commercial dust containing deltamethrin by heating the material as purchased. Tarsal contact bioassays were conducted to investigate its efficacy, potency, and speed of action against resistant Anopheles populations compared to the commercially available form of deltamethrin dust. In all cases, D-Fense Dust heated to generate the more active form of deltamethrin was substantially more effective than the commercially available formulation. 100% of both Banfora M and Kisumu populations were knocked down 10 min post-exposure with no recovery afterwards. Gaoua-ara and Tiefora strains exhibited 100% knockdown within 15 min, and the VK7 2014 strain exhibited 100% knockdown within 20 min. In all cases, 100% mortality was observed 24 h post-exposure. Conversely, the commercial formulation (unheated) resulted in less than 4% mortality amongst VK7 2014, Banfora, and Gaoua-ara populations by 24 h, and Tiefora and Kisumu mosquitoes experienced 14 and 47% mortality by 24 h, respectively. The heat-activated dust maintained comparable efficacy 13 months after heating. The heat-activated form of commercial deltamethrin D-Fense Dust outperformed the material as purchased, dramatically increasing efficacy against all tested pyrethroid-resistant strains. This increase in lethality was retained for 13 months of storage under ambient conditions in the laboratory. Higher energy forms of commonly used insecticides may be employed to overcome various resistance mechanisms seen in African Anopheles mosquitoes through more rapid uptake of insecticide molecules from their respective solid surfaces. That is, resistant mosquitoes can be killed with an insecticide to which they are resistant without altering the molecular composition of the insecticide.
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影响因子：
5.9
作者：
Adams KL;Sawadogo SP;Nignan C;Niang A;Paton DG;Robert Shaw W;South A;Wang J;Itoe MA;Werling K;Dabiré RK;Diabaté A;Catteruccia F
通讯作者：
Catteruccia F
影响因子：
16.6
作者：
Yang, Jingxiang;Hu, C. T.;Kahr, Bart
通讯作者：
Kahr, Bart
DOI：
10.1073/pnas.2013390117
发表时间：
2020-10-27
影响因子：
11.1
作者：
Yang, Jingxiang;Erriah, Bryan;Kahr, Bart
通讯作者：
Kahr, Bart
影响因子：
64.8
作者：
ELLIOTT, M;FARNHAM, AW;PULMAN, DA
通讯作者：
PULMAN, DA
DOI：
10.1073/pnas.1608295113
发表时间：
2016-08-16
影响因子：
11.1
作者：
Balabanidou, Vasileia;Kampouraki, Anastasia;Vontas, John
通讯作者：
Vontas, John