Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease.
Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease.
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DOI：
10.3390/nu13072143
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发表时间：
2021-06-22
期刊：
影响因子：
5.9
通讯作者：
Koutakis P
中科院分区：
文献类型：
--
作者：
Ismaeel A;Greathouse KL;Newton N;Miserlis D;Papoutsi E;Smith RS;Eidson JL;Dawson DL;Milner CW;Widmer RJ;Bohannon WT;Koutakis P
外周动脉疾病（PAD）影响全球超过2亿人，导致显著的发病率和死亡率，但治疗选择仍然有限。PAD的表现之一是严重的功能障碍和下降，这被认为是不同病理生理机制的结果，包括氧化应激、骨骼肌病理和一氧化氮生物利用度降低。因此，靶向这些机制的化合物可能对PAD患者的行走能力具有治疗效果。植物产生的植物化学物质因其潜在的健康效应和在包括心血管疾病和癌症在内的各种疾病中的作用而被广泛研究。在这篇综述中，我们着重于PAD，并讨论了与不同植物化学物质的临床效用相关的证据。我们讨论了植物化学研究在临床前模型的PAD，我们强调了现有的临床试验的结果，评估了这些化合物对PAD患者的功能结果的影响。
Peripheral artery disease (PAD) affects over 200 million people worldwide, resulting in significant morbidity and mortality, yet treatment options remain limited. Among the manifestations of PAD is a severe functional disability and decline, which is thought to be the result of different pathophysiological mechanisms including oxidative stress, skeletal muscle pathology, and reduced nitric oxide bioavailability. Thus, compounds that target these mechanisms may have a therapeutic effect on walking performance in PAD patients. Phytochemicals produced by plants have been widely studied for their potential health effects and role in various diseases including cardiovascular disease and cancer. In this review, we focus on PAD and discuss the evidence related to the clinical utility of different phytochemicals. We discuss phytochemical research in preclinical models of PAD, and we highlight the results of the available clinical trials that have assessed the effects of these compounds on PAD patient functional outcomes.
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影响因子：
7.8
作者：
Bose C;Alves I;Singh P;Palade PT;Carvalho E;Børsheim E;Jun SR;Cheema A;Boerma M;Awasthi S;Singh SP
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DOI：
10.1152/ajpheart.00163.2015
发表时间：
2015-07-15
影响因子：
4.8
作者：
Bradley, Jessica M.;Islam, Kazi N.;Lefer, David J.
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