Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism.

Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism.
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DOI:
10.1016/j.ceb.2013.01.010
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发表时间:
2013-04
影响因子:
7.5
通讯作者:
Lin, Haifan
Lin, Haifan
中科院分区:
生物学2区
文献类型:
--
作者:
Peng, Jamy C.;Lin, Haifan

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Piwi相互作用RNA(piRNA)在2006年被报道为与Argonaute/Piwi家族的Piwi蛋白相关的一类新的小的非编码RNA。最近的研究不仅揭示了piRNA的生物起源及其在转座子沉默中的作用,而且还揭示了Piwi-piRNA途径在基因表达的表观遗传和转录后调控中的功能。此外,该途径在体细胞中的功能也得到了更系统的表征。新的发现揭示了Piwi-piRNA途径是一种更普遍的基因调控机制。
Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigenetic and post-transcriptional regulation of gene expression. In addition, the function of this pathway in somatic cells has also been more systematically characterized. The new findings reveal the Piwi-piRNA pathway as a more general mechanism of gene regulation.
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