Vulnerability to simple faints is predicted by regional differences in brain anatomy.
Vulnerability to simple faints is predicted by regional differences in brain anatomy.
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DOI：
10.1016/j.neuroimage.2009.05.038
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发表时间：
2009-09
期刊：
影响因子：
5.7
通讯作者：
Critchley, Hugo D.
中科院分区：
文献类型：
--
作者：
Beacher, Felix D. C. C.;Gray, Marcus A.;Mathias, Christopher J.;Critchley, Hugo D.
关键词：
神经心源性晕厥（NCS，单纯性昏厥）是一种常见且典型的良性家族性疾病，很少会导致创伤性损伤或缺氧性惊厥。NCS与情绪触发、焦虑状态和压力有关。然而，NCS的病因，作为一个心理生理过程，是知之甚少。因此，我们调查NCS和脑解剖之间的关系。我们研究了一个非临床样本的18个人的历史特征的NCS，和19个匹配的对照谁从来没有晕倒。我们记录了昏厥频率、静息心率变异性测量和焦虑水平。在1.5 T下采集结构T1加权磁共振图像（MRI）。使用基于体素的形态测量法（VBM）测试脑形态测量（区域灰质和白色物质体积）与NCS、静息生理学和焦虑之间的关联。与对照组相比，NCS参与者在延髓和中脑（先验感兴趣区域）内的局部脑体积较低。此外，在NCS个体中，左尾状核邻近区域的灰质体积较低，可预测副交感神经心脏张力、昏厥频率和焦虑水平的增强。我们的研究结果提供了初步证据的层次解剖学基础，以NCS。首先，支持心血管稳态的脑干中心容量的差异可能与NCS的体质易感性有关。第二，NCS个体尾状核结构组织的差异可能与昏厥频率有关，这是通过情绪状态和心脏副交感神经控制之间的相互作用实现的。这些观察结果突出了VBM的应用，以确定相关的心身医学和情绪的神经科学的神经内脏机制。
Neurocardiogenic syncope (NCS, simple fainting) is a common and typically benign familial condition, which rarely may result in traumatic injury or hypoxic convulsions. NCS is associated with emotional triggers, anxiety states and stress. However, the etiology of NCS, as a psychophysiological process, is poorly understood. We therefore investigated the relationship between NCS and brain anatomy. We studied a non-clinical sample of eighteen individuals with histories characteristic of NCS, and nineteen matched controls who had never fainted. We recorded fainting frequency, resting heart rate variability measures and anxiety levels. Structural T1-weighted magnetic resonance images (MRI) were acquired at 1.5 T. Associations between brain morphometry (regional gray and white matter volumes) and NCS, resting physiology and anxiety were tested using voxel-based morphometry (VBM). Compared to controls, NCS participants had lower regional brain volume within medulla and midbrain (a priori regions of interest). Moreover, across NCS individuals, lower gray matter volume in contiguous regions of left caudate nucleus predicted enhanced parasympathetic cardiac tone, fainting frequency and anxiety levels. Our findings provide preliminary evidence for a hierarchical anatomical basis to NCS. First, differences in the volume of brainstem centers supporting cardiovascular homeostasis may relate to constitutional predisposition to NCS. Second, differences in the structural organization of the caudate nucleus in NCS individuals may relate to fainting frequency via interactions between emotional state and parasympathetic control of the heart. These observations highlight the application of VBM to the identification of neurovisceral mechanisms relevant to psychosomatic medicine and the neuroscience of emotion.
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DOI：
10.1111/j.1540-8159.1997.tb03905.x
发表时间：
1997-03-01
影响因子：
1.8
作者：
Ellenbogen, KA;Morillo, CA;Smith, ML
通讯作者：
Smith, ML
影响因子：
6
作者：
Ginestroni, Andrea;Della Nave, Riccardo;Mascalchi, Mario
通讯作者：
Mascalchi, Mario
影响因子：
158.5
作者：
Grubb, BP
通讯作者：
Grubb, BP
DOI：
10.1152/ajpheart.1998.274.6.h2110
发表时间：
1998-06-01
影响因子：
4.8
作者：
Jardine, DL;Ikram, H;Crozier, IG
通讯作者：
Crozier, IG
影响因子：
10.6
作者：
FRIEDMAN, BH;THAYER, JF;COLUMBO, R
通讯作者：
COLUMBO, R