Nicotine Abstinence Influences the Calculation of Salience in Discrete Insular Circuits.
Nicotine Abstinence Influences the Calculation of Salience in Discrete Insular Circuits.
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DOI：
10.1016/j.bpsc.2017.09.010
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Stein EA
中科院分区：
文献类型：
--
作者：
Fedota JR;Ding X;Matous AL;Salmeron BJ;McKenna MR;Gu H;Ross TJ;Stein EA
岛叶分区显示出与特定大脑区域不同的静息态功能连接（rsFC）模式，每种模式都有不同的功能意义。这些细分中的种子用于表征急性尼古丁戒断对岛叶细分和与成瘾和注意力控制有关的大脑网络之间的 rsFC 的影响。在受试者内部设计中，从寻求治疗的吸烟者（n = 20）在吸烟饱腹感后以及在戒除尼古丁 48 小时后再次收集静息态 BOLD 数据。三个感兴趣的右半球岛叶区域（背侧、腹侧和后侧）作为分析的种子。获得了静态和动态 rsFC 指数，并将其与主观退缩和行为表现指数相关联。观察到禁欲引起的生理、主观和认知差异。戒烟期间总体动态 rsFC 降低，包含每个岛状种子的回路显示 rsFC 随尼古丁戒断的变化而变化。具体来说，背侧和后岛与默认模式和显着网络的连接得到增强，而先前未描述的腹侧岛与执行控制网络的连接则减少。此外，静态 rsFC 与改良的腹侧和后岛种子回路中厌恶情绪和退缩的主观评级显着相关。正如预测的那样，在禁欲期间观察到岛叶分区和反相关静息大脑网络之间存在不同的连接。这些变化反映了对厌恶情感处理的注意力偏差，而不是直接远离外源认知处理，这表明与内感受和情感处理相关的回路的协调调节，在尼古丁戒断期间实例化了厌恶状态。
Insular subdivisions show distinct patterns of resting state functional connectivity (rsFC) with specific brain regions, each with different functional significance. Seeds in these subdivisions are employed to characterize the effects of acute nicotine abstinence on rsFC between insula subdivisions and brain networks implicated in addiction and attentional control. In a within subjects design, resting-state BOLD data were collected from treatment-seeking smokers (n=20) following smoking satiety and again following 48 hours of nicotine abstinence. Three right hemisphere insular regions of interest (dorsal, ventral, and posterior) served as seeds for analyses. Indices of both static and dynamic rsFC were obtained and correlated with indices of subjective withdrawal and behavioral performance. Abstinence-induced physiological, subjective, and cognitive differences were observed. Overall dynamic rsFC was reduced during abstinence, and circuits containing each insular seed showed changes in rsFC as a function of nicotine abstinence. Specifically, dorsal and posterior insular connections to the default mode and salience networks were enhanced, while a previously undescribed ventral insular connection to the executive control network was reduced. Further, static rsFC was significantly correlated with subjective ratings of aversive affect and withdrawal in the modified ventral and posterior insular-seeded circuits. As predicted, divergent connections between insula subdivisions and anticorrelated resting brain networks were observed during abstinence. These changes reflect an attentional bias toward aversive affective processing and not directly away from exogenous cognitive processing, suggesting a coordinated modulation of circuits associated with interoceptive and affective processing that instantiates an aversive state during nicotine abstinence.
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1111/add.13061
发表时间：
2015-12
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Abdolahi A;Williams GC;Benesch CG;Wang HZ;Spitzer EM;Scott BE;Block RC;van Wijngaarden E
通讯作者：
van Wijngaarden E
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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通讯作者：
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影响因子：
16.2
作者：
Calhoun, Vince D.;Miller, Robyn;Pearlson, Godfrey;Adali, Tulay
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