Greater velocity and magnitude of airway narrowing in immature than in mature rabbit lung explants.
Greater velocity and magnitude of airway narrowing in immature than in mature rabbit lung explants.
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与成熟兔肺外植体相比，未成熟兔肺外植体气道狭窄的速度和幅度更大。
DOI：
10.1164/ajrccm.164.9.2011045
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Tepper,RS
中科院分区：
文献类型：
--
作者：
Duguet,A;Wang,CG;Gomes,R;Ghezzo,H;Eidelman,DH;Tepper,RS
Methacholine (MCh)-induced bronchoconstrictionin vivoproduces greater maximal increases in pulmonary and airway resistances in immature than in mature rabbits. Our recent findings of lower shear modulus and greater airway distensibility suggest a lower elastic load limiting airway smooth muscle (ASM) shortening in immature rabbit lungs. We hypothesized that a lower elastic load should result in greater velocity of airway narrowing. Lung explants were prepared from three immature and five mature rabbits. Dynamic narrowing of intraparenchymal airways after maximal MCh stimulation was assessed by video microscopy. Immature airways (n = 80) compared with mature airways (n = 110) demonstrated greater peak velocity of shortening (6.98 ± 0.32 versus 4.22 ± 0.18% of baseline perimeter/s) and greater maximal airway narrowing, expressed as percentage of baseline area (31.9 ± 1.6 versus 42.2 ± 1.8%). For both groups, a greater velocity of shortening resulted in greater airway narrowing. As available data do not support maturational differences in rabbit ASM, our results are consistent with a lower elastic load limiting ASM shortening in the immature rabbit.
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猪气管缩短速度的个体发育。
DOI：
10.1152/ajplung.1992.262.3.l280
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Ikeda,K;Mitchell,RW;Guest,KA;Seow,CY;Kirchhoff,CF;Murphy,TM;Leff,AR
通讯作者：
Leff,AR
液态镓铝共晶合金溅射过程中的团簇发射
影响因子：
3.2
作者：
T. Lill;W. Calaway;M. Pellin
通讯作者：
M. Pellin
跨肺压对未成熟和成熟兔气道闭合的影响。
DOI：
10.1152/jappl.1995.78.2.505
发表时间：
1995
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Tepper,RS;Gunst,SJ;Doerschuk,CM;Shen,X;Bray,W
通讯作者：
Bray,W
影响因子：
3.3
作者：
SEOW, CY;STEPHENS, NL
通讯作者：
STEPHENS, NL
两种高度近交系大鼠的体外支气管反应性。
影响因子：
3.3
作者：
C. G. Wang;J. Almirall;C. Dolman;R. Dandurand;D. Eidelman
通讯作者：
D. Eidelman