A randomized controlled trial examining Iyengar yoga for young adults with rheumatoid arthritis: a study protocol.
A randomized controlled trial examining Iyengar yoga for young adults with rheumatoid arthritis: a study protocol.
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DOI：
10.1186/1745-6215-12-19
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发表时间：
2011-01-21
期刊：
影响因子：
2.5
通讯作者：
Zeltzer LK
中科院分区：
文献类型：
--
作者：
Evans S;Cousins L;Tsao JC;Subramanian S;Sternlieb B;Zeltzer LK
类风湿性关节炎是一种慢性致残性疾病，会影响活动能力、日常功能和健康相关的生活质量，特别是对于年龄较大的青少年和年轻人。在这个项目中，我们将针对患有类风湿性关节炎的年轻人制定的标准化艾扬格瑜伽计划与标准护理等待名单控制条件进行比较。 70 名 16-35 岁的类风湿性关节炎患者将被随机分配到为期 6 周的艾扬格瑜伽课程（每周两次，每次 12 - 1.5 小时）或为期 6 周的候补对照条件组。预计流失率为 20%。等待名单上的小组将在第一部分研究完成后接受瑜伽课程。我们将使用问卷和疾病活动标记定量收集数据，并使用半结构化访谈定性收集数据。评估包括一般和关节炎特异性功能、疼痛、情绪和健康相关生活质量的标准化测量，以及定性访谈、血压/静息心率测量、体检和促炎细胞因子的评估。数据将收集三次：治疗前、治疗后和治疗后两个月。这项研究的结果将为增强类风湿关节炎患者功能的非药物方法提供关键数据。特别是，结果将揭示针对类风湿关节炎症状的新型干预措施的可行性和潜在功效，为更大规模的临床试验铺平道路。 ClinicalTrials.gov NCT01096823
Rheumatoid arthritis is a chronic, disabling disease that can compromise mobility, daily functioning, and health-related quality of life, especially in older adolescents and young adults. In this project, we will compare a standardized Iyengar yoga program for young people with rheumatoid arthritis to a standard care wait-list control condition. Seventy rheumatoid arthritis patients aged 16-35 years will be randomized into either the 6-week Iyengar yoga program (12 - 1.5 hour sessions twice weekly) or the 6-week wait-list control condition. A 20% attrition rate is anticipated. The wait-list group will receive the yoga program following completion of the first arm of the study. We will collect data quantitatively, using questionnaires and markers of disease activity, and qualitatively using semi-structured interviews. Assessments include standardized measures of general and arthritis-specific function, pain, mood, and health-related quality of life, as well as qualitative interviews, blood pressure/resting heart rate measurements, a medical exam and the assessment of pro-inflammatory cytokines. Data will be collected three times: before treatment, post-treatment, and two months following the treatment. Results from this study will provide critical data on non-pharmacologic methods for enhancing function in rheumatoid arthritis patients. In particular, results will shed light on the feasibility and potential efficacy of a novel intervention for rheumatoid arthritis symptoms, paving the way for a larger clinical trial. ClinicalTrials.gov NCT01096823
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