The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
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DOI：
10.1016/j.immuni.2012.07.016
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发表时间：
2012-11-16
期刊：
影响因子：
32.4
通讯作者：
Blumberg RS
中科院分区：
文献类型：
--
作者：
Chen L;Chen Z;Baker K;Halvorsen EM;da Cunha AP;Flak MB;Gerber G;Huang YH;Hosomi S;Arthur JC;Dery KJ;Nagaishi T;Beauchemin N;Holmes KV;Ho JW;Shively JE;Jobin C;Onderdonk AB;Bry L;Weiner HL;Higgins DE;Blumberg RS
癌胚抗原细胞黏附分子I(CEACAM1)表达于活化的T细胞上，通过一条长的(L)胞浆尾巴和一条短的(S)胞浆尾巴传递信号，该尾巴含有免疫受体酪氨酸抑制基序，具有抑制功能。以往对外周T细胞的研究表明，在小鼠和人中，CEACAM1-L亚型占主导地位，几乎没有检测到CEACAM1-S亚型。在人类和小鼠的肠道T细胞和肠道相关淋巴组织中，CEACAM1-S亚型相对CEACAM1-L亚型的优势表达，我们发现情况并非如此。这种组织驻留的CEACAM1-S表达优势是由肠道环境决定的，在肠道环境中，它具有刺激功能，导致与产生分泌性IgA免疫相关的T细胞亚群的调节，粘膜共生性的调节，以及对肠道病原体的屏障防御。
Carcinoembryonic antigen cell adhesion molecule like I (CEACAM1) is expressed on activated T cells and signals through either a long (L) cytoplasmic tail containing immune receptor tyrosine based inhibitory motifs, which provide inhibitory function, or a short (S) cytoplasmic tail with an unknown role. Previous studies on peripheral T cells show that CEACAM1-L isoforms predominate with little to no detectable CEACAM1-S isoforms in mouse and human. We show here that this was not the case in tissue resident T cells of intestines and gut associated lymphoid tissues which demonstrated predominant expression of CEACAM1-S isoforms relative to CEACAM1-L isoforms in human and mouse. This tissue resident predominance of CEACAM1-S expression was determined by the intestinal environment where it served a stimulatory function leading to the regulation of T cell subsets associated with generation of secretory IgA immunity, the regulation of mucosal commensalism, and defense of the barrier against enteropathogens.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
3.7
作者：
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