The microRNA-148/152 family: multi-faceted players.

The microRNA-148/152 family: multi-faceted players.
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MicroRNA-148/152 家族:多面手

DOI:
10.1186/1476-4598-12-43
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发表时间:
2013-05-19
期刊:
影响因子:
37.3
通讯作者:
Wang ZN
Wang ZN
中科院分区:
医学1区
文献类型:
--
作者:
Chen Y;Song YX;Wang ZN

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MicroRNA(miRNA)是一类非编码RNA,其长度约为19-23个核苷酸,在许多生物学过程中起着重要作用。microRNA-148/152(miR-148/152)家族成员包括microRNA-148 a(miR-148 a)、microRNA-148 b(miR-148 b)和microRNA-152(miR-152),它们在肿瘤和非肿瘤组织中表达不同,并参与疾病的发生和发展。此外,miR-148/152家族的成员在正常组织的生长和发育中是重要的。miR-148/152家族成员调节靶基因,并受CPG岛甲基化的调节。本文就miR-148/152家族成员、CPG岛甲基化及其靶基因在不同疾病和正常组织中的表达进行综述。
MicroRNAs(miRNA) are noncoding RNAs of about 19–23 nucleotides that are crucial for many biological processes. Members of the microRNA-148/152(miR-148/152) family, which include microRNA-148a(miR-148a), microRNA-148b(miR-148b), and microRNA-152(miR-152), are expressed differently in tumor and nontumor tissues and are involved in the genesis and development of disease. Furthermore, members of the miR-148/152 family are important in the growth and development of normal tissues. Members of the miR-148/152 family regulate target genes and are regulated by methylation of CPG islands. In this review, we report recent studies on the expression of members of the miR-148/152 family, methylation of CPG islands, and their target genes in different diseases, as well as in normal tissues.
DOI: 10.1093/nar/gks025
发表时间: 2012-05
影响因子: 14.9
作者:
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