Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.
Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.
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DOI：
10.1371/journal.pone.0044743
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Matsuda K
中科院分区：
文献类型：
--
作者：
Kumar V;Yi Lo PH;Sawai H;Kato N;Takahashi A;Deng Z;Urabe Y;Mbarek H;Tokunaga K;Tanaka Y;Sugiyama M;Mizokami M;Muroyama R;Tateishi R;Omata M;Koike K;Tanikawa C;Kamatani N;Kubo M;Nakamura Y;Matsuda K
MHC I类多肽相关链A（云母）分子在病毒感染和各种类型的应激反应中被诱导。我们最近报道了位于云母启动子区域的单核苷酸多态性（SNP）rs 2596542与丙型肝炎病毒（HCV）诱导的肝细胞癌（HCC）的风险显著相关，也与血清可溶性云母（sMICA）水平显著相关。本研究旨在探讨云母云母多态性与B型肝炎病毒（HBV）感染相关的肝癌发生的关系，并检测HBV诱导的肝癌患者血清sMICA水平与MICA基因多态性的相关性。遗传关联分析显示与SNP rs 2596542的名义关联; G等位基因被认为增加HBV诱导的HCC的风险（P = 0.029，优势比为1.19）。 我们还发现sMICA在HBV诱导的HCC病例中显著升高。此外，SNP rs 2596542的G等位基因与增加的sMICA水平显著相关（P = 0.009）。 血清sMICA水平高（>5 pg/ml）的HCC患者预后差于血清sMICA水平低（≤5 pg/ml）的HCC患者（P = 0.008）。 因此，我们的研究结果强调了云母遗传变异的重要性和sMICA作为HBV诱导的HCC的预测生物标志物的意义。
MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC.
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