A corset function of exoskeletal ECM promotes body elongation in Drosophila.
A corset function of exoskeletal ECM promotes body elongation in Drosophila.
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DOI：
10.1038/s42003-020-01630-9
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发表时间：
2021-01-19
影响因子：
5.9
通讯作者：
Kojima T
中科院分区：
文献类型：
--
作者：
Tajiri R;Fujiwara H;Kojima T
身体伸长是发育的一般特征。胚后时期，身体需要由细胞外材料来构建和保护，如骨骼，皮肤和外壳，这些材料比细胞具有更大的强度。因此，胚胎发生后的身体伸长必须与这些刚性的细胞外物质相协调。在这里，我们表明，外骨骼（角质层）涂层的果蝇幼虫身体的机械性能，扩展效率较低，沿着身体周长比沿着前后轴。角质层的这种“紧身胸衣”性质在身体生长期间引导身体形状的变化，从相对圆的形状到细长的形状。此外，紧身衣的性能取决于角质层蛋白11 A和Tubby的功能，角质层蛋白11 A和Tubby是幼虫角质层亚表层的蛋白质组分。因此，构建一个可拉伸的角质层，并提供它的组件，赋予圆周刚度是苍蝇的策略执行胚后身体伸长。Tajiri等人描述了覆盖果蝇幼虫身体的角质层如何沿着身体圆周沿着比沿着沿着前后轴更有效地扩张以驱动身体伸长。这种“紧身胸衣”的特性取决于表皮蛋白Cpr11A和Tubby，它们可能共同作用以改变幼虫的体形。
Body elongation is a general feature of development. Postembryonically, the body needs to be framed and protected by extracellular materials, such as the skeleton, the skin and the shell, which have greater strength than cells. Thus, body elongation after embryogenesis must be reconciled with those rigid extracellular materials. Here we show that the exoskeleton (cuticle) coating the Drosophila larval body has a mechanical property to expand less efficiently along the body circumference than along the anteroposterior axis. This “corset” property of the cuticle directs a change in body shape during body growth from a relatively round shape to an elongated one. Furthermore, the corset property depends on the functions of Cuticular protein 11 A and Tubby, protein components of a sub-surface layer of the larval cuticle. Thus, constructing a stretchable cuticle and supplying it with components that confer circumferential stiffness is the fly’s strategy for executing postembryonic body elongation. Tajiri et al. describe how the cuticle coating the Drosophila larval body expands less efficiently along the body circumference than along the anteroposterior axis to drive body elongation. This “corset” property depends on cuticular proteins Cpr11A and Tubby, which may work together to change larval body shape.
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影响因子：
7.7
作者：
Crest, Justin;Diz-Munoz, Alba;Bilder, David
通讯作者：
Bilder, David
DOI：
10.1126/science.1199424
发表时间：
2011-02-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Haigo SL;Bilder D
通讯作者：
Bilder D
影响因子：
1.9
作者：
Bakker, K.
通讯作者：
Bakker, K.
影响因子：
--
作者：
CHURCH, RB;ROBERTSON, FW
通讯作者：
ROBERTSON, FW
影响因子：
9.8
作者：
Benton MA
通讯作者：
Benton MA