Molecular Pathological Markers Correlated With the Recurrence Patterns of Glioma.
Molecular Pathological Markers Correlated With the Recurrence Patterns of Glioma.
复制标题
与胶质瘤复发模式相关的分子病理标志物
DOI：
10.3389/fonc.2020.565045
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Ge S;Shi Y;Zhu G;Li S;Cai Y;Ji P;Liu J;Guo W;Gong L;Lou M;Feng F;Wang Y;Zhai Y;Qu Y;Wang L
胶质瘤是中枢神经系统最常见的肿瘤之一，许多患者即使经过标准的综合治疗也会复发。然而，目前对预测胶质瘤复发模式的分子标志物知之甚少。本研究旨在证明分子标志物与胶质瘤复发模式之间的相关性，其中包括局部/非局部复发和室旁/非室旁复发。应用免疫组化技术对88例手术切除的胶质瘤组织进行分子标记物检测。复发模式分为局部复发、边缘复发、远处复发、多次复发和蛛网膜下复发，后四种复发模式统称为非局部复发。根据复发是否侵犯脑室，将非局部复发分为脑室旁复发和非脑室旁复发。然后，我们比较了不同的复发模式和他们的临床特点，重点是分子标志物的表达。非局部复发组接受联合放疗和化疗的患者多于局部复发组（p=0.019）。性别、年龄、手术范围、复发时间、肿瘤位置、大小和WHO分级在定义的组中无差异（P>0.05）。脑室旁复发组和非脑室旁复发组的复发肿瘤体积和WHO分级有显著差异（p=0.046和0.033）。Ki-67、P53和PCNA在非局部复发组中的表达显著高于局部复发组（p=0.015、0.009和0.037），而S-100在非局部复发组中的表达显著低于局部复发组（p=0.015）。考克斯回归分析显示，PCNA高表达与非局部复发相关的风险比（HR）为3.43（95% CI，1.15，10.24），MGMT高表达与室旁复发相关的HR为2.64（95% CI，1.15，6.08）。Ki-67、P53、PCNA和MGMT可能是判断非局部复发和室旁复发的重要临床指标。
Glioma is one of the most common tumors of the central nervous system, and many patients suffer from recurrence even after standard comprehensive treatment. However, little is known about the molecular markers that predict the recurrence patterns of glioma. This study aimed to demonstrate the correlations between molecular markers and glioma recurrence patterns, which included local/nonlocal recurrence and paraventricular/nonparaventricular recurrence. Immunohistochemical techniques were used to assess the molecular markers of 88 glioma tissues following surgical resection. The recurrence patterns were divided into local recurrence, marginal recurrence, distant recurrence, multirecurrence, and subarachniod recurrence, with the last four recurrence patterns being collectively called nonlocal recurrence. According to whether the recurrence invaded ventricles, the nonlocal recurrence patterns were divided into paraventricular and nonparaventricular recurrence. Then, we compared the different recurrence patterns and their clinical characteristics, focusing on the expression of molecular markers. More patients in the nonlocal recurrence group received combined radiotherapy and chemotherapy than patients in the local recurrence group (p=0.019). Sex, age, extent of surgery, time to recurrence, tumor location, size, and WHO grade were not different in the defined groups (P>0.05). Recurrent tumor volume and WHO grade were significantly different between the paraventricular and nonparaventricular recurrence groups (p=0.046 and 0.033). The expression of Ki-67, P53, and PCNA in the nonlocal recurrence group was significantly higher than that in the local recurrence group (p=0.015, 0.009, and 0.037), while the expression of S-100 in the nonlocal recurrence group was significantly lower than that in the local recurrence group (p=0.015). Cox regression indicated hazard ratio (HR) for high expression level of PCNA associated with non-local recurrence was 3.43 (95% CI, 1.15, 10.24), and HR for high expression level of MGMT associated with paraventricular recurrence was 2.64 (95% CI, 1.15,6.08). Ki-67, P53, PCNA, and MGMT might be important clinical markers for nonlocal recurrence and paraventricular recurrence.
登录
查看更多内容
影响因子：
4.1
作者：
Lau, Darryl;Hervey-Jumper, Shawn L.;Berger, Mitchel S.
通讯作者：
Berger, Mitchel S.
影响因子：
3.5
作者：
Ellingson, B. M.;Lai, A.;Cloughesy, T. F.
通讯作者：
Cloughesy, T. F.
DOI：
10.1007/978-3-319-12048-5_2
发表时间：
2015-01-01
期刊：
CURRENT UNDERSTANDING AND TREATMENT OF GLIOMAS
影响因子：
--
作者：
Cohen, Adam L.;Colman, Howard
通讯作者：
Colman, Howard
影响因子：
2
作者：
Li, Jiaoming;Niu, Xiaodong;Mao, Qing
通讯作者：
Mao, Qing
影响因子：
1.9
作者：
Konishi, Yoshiyuki;Muragaki, Yoshihiro;Okada, Yoshikazu
通讯作者：
Okada, Yoshikazu