Anti-DNA antibodies cross-react with C1q.
Anti-DNA antibodies cross-react with C1q.
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DOI：
10.1016/j.jaut.2013.06.002
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发表时间：
2013-08
影响因子：
12.8
通讯作者：
Diamond B
中科院分区：
文献类型：
--
作者：
Franchin G;Son M;Kim SJ;Ben-Zvi I;Zhang J;Diamond B
系统性红斑狼疮(SLE)是一种累及多个器官系统的自身免疫性疾病，通常表现为慢性炎症性疾病。抗双链(DS)DNA抗体存在于约70%的患者中，并形成含有核酸的免疫复合体，通过与Toll样受体的结合激活树突状细胞，导致促炎、亲免疫环境。此外，抗dsDNA抗体沉积在肾脏中，引发肾小球肾炎。抗C1q抗体也与狼疮性肾炎有关，在30%-50%的患者中发现了这种抗体。C1q是已知的免疫激活抑制因子，C1q缺乏是SLE的最大危险因素。我们之前发现了一组与N-甲基-d-天冬氨酸受体结合的抗DNA抗体。我们现在证明，具有这种特异性的鼠和人的抗DNA抗体都能结合C1q。这些抗体与肾小球中的Clq结合，并在没有C1q的情况下表现出肾小球沉积减少。我们认为，这类抗DNA抗体通过直接靶向肾小球的C1q和清除可溶性C1q参与狼疮的发病，从而限制了C1q调节免疫稳态的能力。
Systemic lupus erythematosus (SLE) is an autoimmune disorder that involves multiple organ systems and typically presents as a chronic inflammatory disease. Antibodies to double-stranded (ds) DNA are present in approximately 70% of patients and form nucleic acid containing immune complexes which activate dendritic cells through engagement of toll-like receptors, leading to a pro-inflammatory, pro-immunogenic milieu. In addition, anti-dsDNA antibodies deposit in kidneys to initiate glomerulonephritis. Antibodies to C1q have also been implicated in lupus nephritis and are found in 30–50% of patients. C1q is a known suppressor of immune activation and C1q deficiency is the strongest risk factor for SLE. We previously identified a subset of anti-DNA antibodies that binds the N-methyl-d-aspartate receptor. We now show that both mouse and human anti-DNA antibodies with this specificity bind C1q. These antibodies bind to Clq in glomeruli and exhibit decreased glomerular deposition in the absence of C1q. We propose that this subset of anti-DNA antibodies participates in lupus pathogenesis through direct targeting of C1q on glomeruli and also through removal of soluble C1q thereby limiting the ability of C1q to mediate immune homeostasis.
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双链DNA（DSDNA）的肽替代物免疫可诱导自身抗体的产生和肾脏免疫球蛋白沉积。
影响因子：
15.3
作者：
Putterman, C;Diamond, B
通讯作者：
Diamond, B
DOI：
10.1073/pnas.0608397104
发表时间：
2006-12-26
影响因子：
11.1
作者：
Kowal, Czeslawa;DeGiorgio, Lorraine A.;Diamond, Betty
通讯作者：
Diamond, Betty
影响因子：
3.6
作者：
Tan, Ying;Zhou, Wei;Zhao, Ming-hui
通讯作者：
Zhao, Ming-hui
影响因子：
15.9
作者：
Budhai, L;Oh, K;Davidson, A
通讯作者：
Davidson, A
DOI：
10.4049/jimmunol.1001731
发表时间：
2010-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Santer DM;Hall BE;George TC;Tangsombatvisit S;Liu CL;Arkwright PD;Elkon KB
通讯作者：
Elkon KB