Protein N-glycosylation and O-mannosylation are catalyzed by two evolutionarily related GT-C glycosyltransferases.

Protein N-glycosylation and O-mannosylation are catalyzed by two evolutionarily related GT-C glycosyltransferases.
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蛋白质N-糖基化和O-甘露糖基化由两种进化上相关的GT-C糖基转移酶催化。

DOI:
10.1016/j.sbi.2020.12.009
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发表时间:
2021-06
影响因子:
6.8
通讯作者:
Li H
Li H
中科院分区:
生物学2区
文献类型:
--
作者:
Bai L;Li H

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The structural folds of glycosyltransferases are categorized into three superfamilies: GT-A, GT-B, and GT-C. Few structures of GT-C fold existed in the Protein Data Bank prior to the recent advent of high-resolution cryo-EM, because the glycosyltransferases are large membrane proteins that are difficult to crystallize. The use of cryo-EM has resulted in the structures of several key GT-C glycosyltransferases. Here we summarize the latest structural features of and mechanistic insights into these membrane enzyme complexes.
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