A highly selective fluorescent sensor for glucosamine

A new fluorescent chemical sensor for glucosamine is reported. The sensor is based on a boronic acid-containing coumarin aldehyde and shows excellent selectivity for glucosamine by forming a boronic ester with the sugar diol as well as an iminium ion with the amine group of glucosamine. The sensor successfully discriminates glucosamine over other similar biomolecules in terms of both fluorescence intensity and binding affinity. This method provides a new concept for the design and synthesis of very selective turn-on optical sensors for selective detection of multi-functional biomolecules.

报道了一种用于氨基葡萄糖的新型荧光化学传感器。该传感器基于一种含硼酸的香豆素醛，通过与糖二醇形成硼酸酯以及与氨基葡萄糖的胺基形成亚胺离子，对氨基葡萄糖表现出优异的选择性。该传感器在荧光强度和结合亲和力方面都能成功区分氨基葡萄糖与其他类似的生物分子。这种方法为设计和合成用于选择性检测多功能生物分子的高选择性开启型光学传感器提供了一个新概念。