Lipid class and fatty acid composition of brain lipids from Atlantic herring (Clupea harengus) at different stages of development
Lipid class and fatty acid composition of brain lipids from Atlantic herring (Clupea harengus) at different stages of development
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不同发育阶段大西洋鲱鱼（Clupea harengus）脑脂质的脂质类别和脂肪酸组成
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
D. Tocher
中科院分区：
文献类型：
--
作者：
G. Mourente;D. Tocher
鱼类脑脂质和脂肪酸组成在不同发育阶段的变化知之甚少。野生大西洋鲱鱼（Clupea harengus L.）1990年8月至1991年3月，从苏格兰的洛赫和克莱德湾采集。在卵黄囊期末的幼虫、两个少年期和性成熟的成虫四个不同的发育阶段，研究了脑脂质的脂类和脂肪酸组成。脑中的总脂质含量增加，在发展过程中，和幼虫的大脑含有较高比例的中性脂质和较低比例的极性脂质比青少年或成年鲱鱼的大脑。青少年和成年鲱鱼脑中的极性脂质的比例增加，主要是由于增加的百分比的磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂和硫酸酯。糖脂类比例的增加表明髓鞘形成水平随着发育而增加。在总脂质中，从幼虫到成虫，饱和脂肪酸普遍减少，单不饱和脂肪酸和二甲基缩醛（来自PE-缩醛）增加。然而，多不饱和脂肪酸的比例在个别磷酸甘油酯一般是最高的，在少年阶段，主要是由于增加22：6n-3，并在成鱼最低。相对较高的百分比24：1异构体中发现所有的磷酸甘油酯，但主要是PC，这些从幼虫到成人的发展过程中增加。脂肪酸分布在个别磷酸甘油酯的特征模式，不随发展而变化，但个别脂肪酸的相对量发生了变化。并结合其它鱼类和脊椎动物脑中脂质的组成和功能，讨论了青鱼脑中不同脂质成分的变化和作用。
Little is known about the changes in composition of brain lipids and fatty acids at different stages of development in fish. Wild Atlantic herring (Clupea harengus L.) were collected from Loch Linnhe and the Firth of Clyde, Scotland, from August 1990 to March 1991. Lipid class and fatty acid compositions of brain lipids were studied at four different stages of development: larvae at the end of the yolk sac stage, two juvenile stages and sexually mature adults. The total lipid content in brains increased during development, and larval brains contained higher proportions of neutral lipids and lower proportions of polar lipids than the brains of juvenile or adult herring. Increased proportions of polar lipids in juvenile and adult herring brains were mainly due to increased percentages of phosphatidylcholine (PC), phosphatidylethanolamine (PE), cerebrosides and sulphatides. The increase in the proportions of the glycolipid classes suggested increasing levels of myelination with development. In total lipids, saturated fatty acids generally decreased and monounsaturated fatty acids and dimethyl acetals (derived from PE-plasmalogen) increased from larvae to adults. However, the proportions of polyunsaturated fatty acids in individual phosphoglycerides were generally highest in juvenile stages, due mainly to increased 22:6n-3, and were lowest in adult fish. Relatively high percentages of 24:1 isomers were found in all the phosphoglycerides, but primarily PC, and these increased during development from larvae to adult. Fatty acids were distributed between individual phosphoglycerides with a characteristic pattern that did not change with development, although the relative amounts of individual fatty acids were altered. The variations and roles of the different lipid components of herring brain are discussed with respect to lipid compositions and functions in brains of other fishes and vertebrates.
DOI：
10.1073/pnas.83.11.4021
发表时间：
1986-06-01
影响因子：
11.1
作者：
NEURINGER, M;CONNOR, WE;LUCK, S
通讯作者：
LUCK, S