Coping as a multisystem construct associated with pathways mediating HIV-relevant immune function and disease progression.

Coping as a multisystem construct associated with pathways mediating HIV-relevant immune function and disease progression.
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应对作为与介导 HIV 相关免疫功能和疾病进展的途径相关的多系统构建。

DOI:
10.1097/psy.0b013e318177354f
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发表时间:
2008
影响因子:
3.3
通讯作者:
Garzino-Demo,Alfredo
Garzino-Demo,Alfredo
中科院分区:
医学3区
文献类型:
--
作者:
Temoshok,LydiaR;Wald,RebeccaL;Synowski,Stephen;Garzino-Demo,Alfredo

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我们回顾了心理神经免疫学研究,将应对艾滋病毒疾病进展及其指标,以及可能调节或促进艾滋病毒进展的病毒和宿主因素联系起来。我们关于应对的观点广泛地涵盖了多种心理和生物系统的尝试,以适应不断变化的内部和环境条件,并重新建立动态平衡。因此,我们讨论了应对的四个维度的研究:认知(评估、期望和解释风格)、情绪(C型应对模式和相关结构)、主动-被动策略和行为模式,以及生理(自主反应和恢复)。最后,我们提出了一个模型,该模型集成了与应对艾滋病毒预后指标和临床疾病进展相关的关键研究。基于经验证据,该模型提出了可信的机制,通过这些机制,应对可能与艾滋病毒进展/抗进展因子和影响艾滋病毒临床进展的免疫病理机制有关。
We review psychoneuroimmunological research linking coping with HIV disease progression and its indicators, as well as with viral and host factors that may mediate or contribute to HIV progression. Our perspective on coping broadly encompasses the attempts of multiple mental and biological systems to adapt to changing internal and environmental conditions and to reestablish homeostasis. Accordingly, we discuss studies within four dimensions of coping: cognitive (appraisals, expectancies, and explanatory style), emotional (the Type C coping pattern and related constructs), active-passive strategies and behavior patterns, and physiological (autonomic reactivity and recovery). Finally, we present a model that integrates key studies linking coping with HIV prognostic indicators and clinical disease progression. Based on empirical evidence, the model suggests plausible mechanisms by which coping may be connected to HIV progression/antiprogression factors and immunopathogenesis to affect HIV clinical progression.
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