Vinculin in cell-cell and cell-matrix adhesions.

Vinculin in cell-cell and cell-matrix adhesions.
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DOI:
10.1007/s00018-017-2511-3
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发表时间:
2017-08
期刊:
Cellular and molecular life sciences : CMLS
影响因子:
--
通讯作者:
DeMali KA
DeMali KA
中科院分区:
其他
文献类型:
--
作者:
Bays JL;DeMali KA

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近40年前,骨钙素被确定为局灶性粘连和粘连连接的一种成分。自那时以来,在了解其激活,调节和功能方面取得了显着进展。在这里,我们讨论了目前的理解粘着斑蛋白在细胞-细胞和细胞-基质粘附的作用。重点放在黏着斑蛋白是如何招募,激活和调节。我们还强调了最近的理解粘着斑蛋白如何响应和传递力的整合素和钙粘蛋白的粘附复合物的细胞骨架。此外,我们还讨论了黏着斑蛋白在肌动蛋白细胞骨架结合和重排中的作用。
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell–cell and cell–matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.
Vinculin磷酸化差异地调节了细胞 - 细胞和细胞矩阵粘附处的机械转导。
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