Cerebral activation by the signals ascending through unmyelinated C-fibers in humans: a magnetoencephalographic study
Cerebral activation by the signals ascending through unmyelinated C-fibers in humans: a magnetoencephalographic study
复制标题
通过人类无髓鞘 C 纤维上升的信号激活大脑：一项脑磁图研究
DOI：
10.1016/s0306-4522(02)00195-1
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发表时间：
2002
期刊：
影响因子：
3.3
通讯作者：
R. Kakigi
中科院分区：
文献类型：
--
作者：
T. Tran;K. Inui;M. Hoshiyama;K. Lam;Y. Qiu;R. Kakigi
与Aδ纤维相关的第一痛的脑加工已被深入研究，但与第二痛相关的无髓C纤维的脑加工仍有待研究。这是第一项通过脑磁图阐明第二次疼痛的初级皮质处理的研究，通过选择性激活C纤维，通过二氧化碳激光刺激皮肤的一小块区域。在刺激侧对侧大脑半球，第一成分1M的最佳构型是位于侧裂上岸(次级体感皮质)的单源发生器或位于次级体感皮质和初级体感皮层手部的双源发生器。两种来源的SI和SII的起始潜伏期和波峰潜伏期无显著差异。在刺激的同侧半球，SII源仅有一个，其峰潜伏期明显长于对侧SII源(平均约18ms)。根据我们的发现，我们认为，刺激对侧的SI和SII的平行激活代表了皮层处理C纤维相关活动的第一步，可能与第二次疼痛有关。
Cerebral processing of first pain, associated with Aδ-fibers, has been studied intensively, but the cerebral processing associated with unmyelinated C-fibers, relating to second pain, remains to be investigated. This is the first study to clarify the primary cortical processing of second pain by magnetoencephalography, through the selective activation of C-fibers, by the stimulation of a tiny area of skin with a CO2laser. In the hemisphere contralateral to the side stimulated, a one-source generator in the upper bank of the Sylvian fissure (secondary somatosensory cortex, SII) or two-source generators in SII and the hand area of the primary somatosensory cortex (SI) were the optimal configurations for the first component 1M. The onset and peak latency of the two sources in SI and SII were not significantly different. In the hemisphere ipsilateral to the stimulation, only one source was estimated in SII, and its peak latency was significantly (approximately 18 ms on average) longer than that of the SII source in the contralateral hemisphere. From our findings we suggest that parallel activation of SI and SII contralateral to the stimulation represents the first step in the cortical processing of C-fiber-related activities, probably related to second pain.
影响因子：
5.5
作者：
OCHOA, J;TOREBJORK, E
通讯作者：
TOREBJORK, E