Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance.
Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance.
复制标题
多形性胶质母细胞瘤（GBM）：目前的治疗和耐药机制的概述。
DOI：
10.1016/j.phrs.2021.105780
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发表时间：
2021-09
影响因子：
9.3
通讯作者：
Daldrup-Link HE
中科院分区：
文献类型：
--
作者：
Wu W;Klockow JL;Zhang M;Lafortune F;Chang E;Jin L;Wu Y;Daldrup-Link HE
多形性胶质母细胞瘤（GBM）是WHO IV级胶质瘤，也是最常见的恶性原发性脑肿瘤，5年生存率为7.2%。其高度浸润性、遗传异质性和血脑屏障（BBB）的保护作用给治疗带来了巨大挑战。GBM的标准治疗是手术切除，然后进行放化疗。胶质母细胞瘤细胞和胶质瘤起始细胞（GIC）的强大DNA修复和自我更新能力分别促进了对所有当前治疗方式的抗性。因此，持久的GBM管理将需要创新的治疗策略的发明。在这篇综述中，我们将描述GBM治疗的生物学和分子靶点，药物治疗的现状，耐药的主要机制和新的治疗方法。迄今为止，医学成像主要用于在治疗之前、期间和之后确定GBM的位置、大小和宏观形态。在未来，分子和细胞成像方法将更动态地监测肿瘤中分子靶标和/或免疫反应的表达，从而能够更直接地适应肿瘤定制的靶向治疗。
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant, primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic heterogeneity, and protection by the blood brain barrier (BBB) have posed great treatment challenges. The standard treatment for GBMs is surgical resection followed by chemoradiotherapy. The robust DNA repair and self-renewing capabilities of glioblastoma cells and glioma initiating cells (GICs), respectively, promote resistance against all current treatment modalities. Thus, durable GBM management will require the invention of innovative treatment strategies. In this review, we will describe biological and molecular targets for GBM therapy, the current status of pharmacologic therapy, prominent mechanisms of resistance, and new treatment approaches. To date, medical imaging is primarily used to determine the location, size and macroscopic morphology of GBM before, during, and after therapy. In the future, molecular and cellular imaging approaches will more dynamically monitor the expression of molecular targets and/or immune responses in the tumor, thereby enabling more immediate adaptation of tumor-tailored, targeted therapies.
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影响因子：
8
作者：
Antonios, Joseph P.;Soto, Horacio;Prins, Robert M.
通讯作者：
Prins, Robert M.
影响因子：
4.7
作者：
Aasland, Dorthe;Reich, Thomas R.;Christmann, Markus
通讯作者：
Christmann, Markus
影响因子：
12.4
作者：
Baran, Katherine;Yang, Mao;Green, Douglas R.
通讯作者：
Green, Douglas R.
影响因子：
5.2
作者：
Andreatta F;Beccaceci G;Fortuna N;Celotti M;De Felice D;Lorenzoni M;Foletto V;Genovesi S;Rubert J;Alaimo A
通讯作者：
Alaimo A
影响因子：
28.4
作者：
Ahmed N;Brawley V;Hegde M;Bielamowicz K;Kalra M;Landi D;Robertson C;Gray TL;Diouf O;Wakefield A;Ghazi A;Gerken C;Yi Z;Ashoori A;Wu MF;Liu H;Rooney C;Dotti G;Gee A;Su J;Kew Y;Baskin D;Zhang YJ;New P;Grilley B;Stojakovic M;Hicks J;Powell SZ;Brenner MK;Heslop HE;Grossman R;Wels WS;Gottschalk S
通讯作者：
Gottschalk S