Human circadian rhythm studies: Practical guidelines for inclusion/exclusion criteria and protocol.
Human circadian rhythm studies: Practical guidelines for inclusion/exclusion criteria and protocol.
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DOI：
10.1016/j.nbscr.2022.100080
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发表时间：
2022-11
影响因子：
--
通讯作者：
DeLorenzo, Christine
中科院分区：
文献类型：
--
作者：
Yousefzadehfard, Yashar;Wechsler, Bennett;DeLorenzo, Christine
As interest in circadian rhythms and their effects continues to grow, there is an increasing need to perform circadian studies in humans. Although the constant routine is the gold standard for these studies, there are advantages to performing more naturalistic studies. Here, a review of protocols for such studies is provided along with sample inclusion and exclusion criteria. Sleep routines, drug use, shift work, and menstrual cycle are addressed as screening considerations. Regarding protocol, best practices for measuring melatonin, including light settings, posture, exercise, and dietary habits are described. The inclusion/exclusion recommendations and protocol guidelines are intended to reduce confounding variables in studies that do not involve the constant routine. Given practical limitations, a range of recommendations is provided from stringent to lenient. The scientific rationale behind these recommendations is discussed. However, where the science is equivocal, recommendations are based on empirical decisions made in previous studies. While not all of the recommendations listed may be practical in all research settings and with limited potential participants, the goal is to allow investigators to make well informed decisions about their screening procedures and protocol techniques and to improve rigor and reproducibility, in line with the objectives of the National Institutes of Health. This review provides critical recommendations for ensuring a rigorous circadian study. When available, recommendations are based on scientific rationale. Empirical decisions are also provided. The goal is to improve rigor and reproducibility of circadian studies.
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DOI：
10.1523/jneurosci.5838-09.2010
发表时间：
2010-07-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Acuna-Goycolea C;Obrietan K;van den Pol AN
通讯作者：
van den Pol AN
影响因子：
5.6
作者：
Burke, Tina M.;Markwald, Rachel R.;Wright, Kenneth P., Jr.
通讯作者：
Wright, Kenneth P., Jr.
影响因子：
6.1
作者：
Bogdan, A;Bouchareb, B;Touitou, Y
通讯作者：
Touitou, Y
影响因子：
2.3
作者：
Brower, Kirk J.
通讯作者：
Brower, Kirk J.
影响因子：
0.9
作者：
Akcoltekin, Alpturk;Engin, Ali Osman;Sevgin, Hikmet
通讯作者：
Sevgin, Hikmet