Intrinsic myoarchitectural differences between the left and right ventricles of fetal human hearts: an ultrasonic backscatter feasibility study.
Intrinsic myoarchitectural differences between the left and right ventricles of fetal human hearts: an ultrasonic backscatter feasibility study.
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胎儿人心脏的左心室和右心室之间的内在肌构造差异：超声波反向散射可行性研究。
DOI：
10.1016/j.echo.2008.11.028
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发表时间：
2009-02
影响因子：
6.5
通讯作者：
Singh, Gautam K.
中科院分区：
文献类型：
--
作者：
Holland, Mark R.;Gibson, Allyson A.;Kirschner, Carol A.;Hicks, Deborah;Ludomirsky, Achiau;Singh, Gautam K.
胚胎学上，心腔从一开始就在形态和收缩特性上不同。我们假设，一个非侵入性的超声背向散射研究可能会说明在心脏发育过程中的两个心室的心肌形态学特性的根本差异。本研究的目的是：1）探讨测量胎儿心脏左、右心室游离壁超声背向散射周期变化幅度的可行性，2）比较左、右心室游离壁超声背向散射周期变化幅度的测量结果，3）比较左、右心室游离壁超声背向散射周期变化幅度的测量结果。以及3）确定所观察到的结果是否与关于总体反向散射水平和周期变化幅度的预测一致。左心室和右心室自由壁的周期变化数据是通过分析16个妊娠中期结构正常胎儿心脏的超声心动图图像的反向散射而生成的。发现左心室游离壁的周期变化幅度大于右心室游离壁（分别为4.5 ± 1.1 dB和2.3 ± 0.9 dB;平均值± SD; p < 0.0001，配对t检验）。可以从胎儿心脏的左侧和右侧获得反向散射的周期变化的测量结果，这表明在左心室和右心室心肌中测量的周期变化幅度之间存在显著差异。这一观察结果与总体后向散射水平和周期变化幅度相关的预测一致。本研究的结果表明，周期性变化的测量可能提供一个有用的方法来表征内在的差异，在评估胎儿心脏发育的两个心室的心肌特性。
Embryologically, cardiac chambers differ in their morphological and contractile properties from the beginning. We hypothesized that a non-invasive ultrasonic backscatter investigation might illustrate the fundamental differences in myocardial morphologic properties of the two ventricles during heart development. The goals of this investigation were: 1) to explore the feasibility of measuring the magnitude of cyclic variation of ultrasonic backscatter from the left and right ventricular free walls of fetal hearts; 2) to compare measurements of the magnitude of cyclic variation from the left and right sides of the heart; and 3) to determine if the observed results are consistent with predictions relating the overall backscatter level and the magnitude of cyclic variation. Cyclic variation data from the left and right ventricular free walls were generated from analyses of the backscatter from echocardiographic images of 16 structurally normal fetal hearts at mid-gestation. The magnitude of cyclic variation was found to be greater for the left ventricular free wall than for the right ventricular free wall (4.5 ± 1.1 dB vs. 2.3 ± 0.9 dB, respectively; mean ± SD; p < 0.0001, paired t-test). Measurements of the cyclic variation of backscatter can be obtained from both the left and right sides of fetal hearts demonstrating a significant difference between the measured magnitude of cyclic variation in the left and right ventricular myocardium. This observation is consistent with predictions relating the overall backscatter level and the magnitude of cyclic variation. Results of this study suggest cyclic variation measurements may offer a useful approach for characterizing intrinsic differences in myocardial properties of the two ventricles in assessing fetal heart development.
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DOI：
10.1016/s0894-7317(98)70134-8
发表时间：
1998-10-01
影响因子：
6.5
作者：
Holland, MR;Wilkenshoff, UM;Miller, JG
通讯作者：
Miller, JG
影响因子：
37.8
作者：
KRYMSKY, LD
通讯作者：
KRYMSKY, LD
DOI：
10.1016/j.echo.2004.04.035
发表时间：
2004-08-01
影响因子：
6.5
作者：
Kovacs, A;Courtois, MR;Miller, JG
通讯作者：
Miller, JG
影响因子：
37.8
作者：
HOYT, RH;COLLINS, SM;CONYERS, D
通讯作者：
CONYERS, D
DOI：
10.1016/j.echo.2004.06.004
发表时间：
2004-11-01
影响因子：
6.5
作者：
Holland, MR;Wallace, KD;Miller, JG
通讯作者：
Miller, JG