A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant.
A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant.
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DOI：
10.1002/jnr.24801
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发表时间：
2022-12
影响因子：
4.2
通讯作者：
Tan, Sidhartha
中科院分区：
文献类型：
--
作者：
Shi, Zhongjie;Luo, Kehuan;Deol, Saihaj;Tan, Sidhartha
新生儿脑病（NE）被标记为缺氧缺血性脑病（HIE），据称是由缺氧缺血引起的。围产期窒息是一种临床综合征，涉及酸中毒、低Apgar评分和需要在产房复苏；窒息提醒人们NE的可能性。在本系统综述中，我们关注脑脊液（CSF）中参与窒息或HIE中可能的脑损伤发展的非炎症性生物标志物。在PubMed和EMBASE中对病例对照研究进行了文献检索，发现有17项研究符合先验标准。统计分析采用Mantel-Haenszel模型对二分类数据进行分析。确定合并平均差和95%置信区间（ci）。我们根据评估生物学意义的估计方法，从三个类别的数百个生物标志物中确定了最佳生物标志物：细胞粘附和增殖，氧化剂和抗氧化剂，以及细胞损伤。进行了以下亚总体人群比较：围产期窒息与无窒息，有HIE的窒息与无HIE的窒息，有HIE的窒息与无窒息，有HIE的窒息与无窒息，足月新生儿与早产儿有窒息的HIE新生儿。生物标记物的生物学意义是通过使用一种改进的估计方法来确定的，通过根据ci界的差异对生物标记物进行排序。最具前景的脑脊液生物标志物包括肌酸激酶、黄嘌呤氧化酶、血管内皮生长因子、神经元特异性烯醇化酶、超氧化物歧化酶和丙二醛。未来的研究建议使用这种联合测试来预测受影响最严重的患者。
Neonatal encephalopathy (NE) that purportedly arises from hypoxia-ischemia is labeled hypoxic-ischemic encephalopathy (HIE). Perinatal asphyxia is a clinical syndrome involving acidosis, a low Apgar score and the need for resuscitation in the delivery room; asphyxia alerts one to the possibility of NE. In the present systematic review, we focused on the noninflammatory biomarkers in cerebrospinal fluid (CSF) that are involved in the development of possible brain injury in asphyxia or HIE. A literature search in PubMed and EMBASE for case-control studies was conducted and 17 studies were found suitable by a priori criteria. Statistical analysis used the Mantel-Haenszel model for dichotomous data. The pooled mean difference and 95% confidence intervals (CIs) were determined. We identified the best biomarkers, based on the estimation approach in evaluating the biological significance, out of hundreds in three categories: cell adhesion and proliferation, oxidants and antioxidants, and cell damage. The following subtotal-population comparisons were made: perinatal asphyxia versus no asphyxia, asphyxia with HIE versus asphyxia without HIE, asphyxia with HIE versus no asphyxia, and term versus preterm HIE newborn with asphyxia. Biological significance of the biomarkers was determined by using a modification of the estimation approach, by ranking the biomarkers according to the difference in the bounds of the CIs. The most promising CSF biomarkers for prognostication especially for the severest HIE include creatine kinase, xanthine oxidase, vascular endothelial growth factor, neuron-specific enolase, superoxide dismutase, and malondialdehyde. Future studies are recommended using such a combined test to prognosticate the most severely affected patients.
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影响因子：
4
作者：
Lo CK;Mertz D;Loeb M
通讯作者：
Loeb M
影响因子：
2.9
作者：
Drobyshevsky, Alexander;Bregman, Joanne;Tan, Sidhartha
通讯作者：
Tan, Sidhartha
影响因子：
3.5
作者：
FERNANDEZ, F;QUERO, J;ROCHE, MC
通讯作者：
ROCHE, MC
影响因子：
3.6
作者：
Juul, SE;Stallings, SA;Christensen, RD
通讯作者：
Christensen, RD
影响因子：
3.1
作者：
Locatelli, Anna;Lambicchi, Laura;Paterlini, Giuseppe
通讯作者：
Paterlini, Giuseppe