The role of snare proteins in cortical development.
The role of snare proteins in cortical development.
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编蛋白在皮质发育中的作用。
DOI：
10.1002/dneu.22892
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发表时间：
2022-09
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
成人神经系统中的神经通讯主要通过化学突触介导，其中动作电位引发Ca 2+信号，其触发突触前室中的囊泡融合和神经递质释放。在发育的早期阶段，大脑是通过营养因子和其他细胞外信号的交流，以及通过接触介导的细胞间相互作用（包括化学突触）形成的。早期神经元冲动和自发和调节的神经递质释放的模式指导轴突投射的精确地形，并有助于确定细胞存活。研究突触囊泡释放机制的特定蛋白质在发育过程中神经元连接的建立、可塑性和维持中的作用只是最近才成为可能，随着小鼠模型的出现，其中N-乙基马来酰亚胺敏感因子附着蛋白受体（SNARE）复合物的各种成员已经被遗传操纵。我们提供了一个概述这些模型，集中在调节囊泡释放和/或细胞兴奋性的作用，在突触组装，开发和维护的皮层电路，细胞存活，电路水平的兴奋抑制平衡，髓鞘形成，细化和可塑性的关键轴突从大脑皮层的预测。这些模型对于理解各种发育和精神疾病以及神经退行性疾病非常重要。
Neural communication in the adult nervous system is mediated primarily through chemical synapses, where action potentials elicit Ca2+ signals, which trigger vesicular fusion and neurotransmitter release in the presynaptic compartment. At early stages of development, the brain is shaped by communication via trophic factors and other extracellular signaling, and by contact‐mediated cell–cell interactions including chemical synapses. The patterns of early neuronal impulses and spontaneous and regulated neurotransmitter release guide the precise topography of axonal projections and contribute to determining cell survival. The study of the role of specific proteins of the synaptic vesicle release machinery in the establishment, plasticity, and maintenance of neuronal connections during development has only recently become possible, with the advent of mouse models where various members of the N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) complex have been genetically manipulated. We provide an overview of these models, focusing on the role of regulated vesicular release and/or cellular excitability in synaptic assembly, development and maintenance of cortical circuits, cell survival, circuit level excitation–inhibition balance, myelination, refinement, and plasticity of key axonal projections from the cerebral cortex. These models are important for understanding various developmental and psychiatric conditions, and neurodegenerative diseases.
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DOI：
10.1073/pnas.1811013115
发表时间：
2018-11-13
影响因子：
11.1
作者：
Dutta DJ;Woo DH;Lee PR;Pajevic S;Bukalo O;Huffman WC;Wake H;Basser PJ;SheikhBahaei S;Lazarevic V;Smith JC;Fields RD
通讯作者：
Fields RD
影响因子：
4.8
作者：
Banerjee, A;Barry, VA;Martin, TFJ
通讯作者：
Martin, TFJ
影响因子：
8.8
作者：
Andreae LC;Burrone J
通讯作者：
Burrone J
影响因子：
5.3
作者：
Augustin, I;Korte, S;Brose, N
通讯作者：
Brose, N
影响因子：
25
作者：
Deken, SL;Beckman, ML;Quick, MW
通讯作者：
Quick, MW