Operation of a brain-computer interface walking simulator for individuals with spinal cord injury.
Operation of a brain-computer interface walking simulator for individuals with spinal cord injury.
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DOI：
10.1186/1743-0003-10-77
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发表时间：
2013-07-17
影响因子：
5.1
通讯作者：
Nenadic Z
中科院分区：
文献类型：
--
作者：
King CE;Wang PT;Chui LA;Do AH;Nenadic Z
脊髓损伤 (SCI) 会使受影响的人出现截瘫或截瘫，从而导致他们无法行走。由于目前尚无针对该人群的恢复性治疗方法，因此人们一直在寻求新的方法，例如大脑控制假体。我们最近的研究表明，脑机接口（BCI）可用于控制虚拟现实环境（VRE）内的行走，这表明BCI控制的下肢假肢用于行走可能是可行的。然而，我们的 BCI 的可操作性尚未在 SCI 人群中进行测试。五名因 SCI 导致截瘫或四肢瘫痪的参与者接受了 10 分钟的训练，训练期间他们交替进行空转和行走的动觉运动想象 (KMI)，同时记录他们的脑电图 (EEG)。然后，参与者执行了一项以目标为导向的在线任务，他们利用 KMI 控制化身的线性移动，同时在 VRE 内的指定点连续停止 10 次。一天内进行了多次在线试验，并在 5 个实验日内重复该过程。空闲和步行的分类准确度是离线估计的，在不同参与者和天数范围内，范围从 60.5% (p = 0.0176) 到 92.3% (p = 1.36×10−20)。离线分析显示，中额叶区域的激活主要集中在 μ 和低 β 带，是区分闲置和行走 KMI 的最一致特征。在在线任务中，参与者在 273±51 秒内平均实现了 7.4±2.3 次成功停止。这些表现是有目的的，即与随机游走蒙特卡罗模拟显着不同（p<0.01），并且除了一名参与者外，所有参与者都在实验的第一天实现了有目的的控制。最后，所有参与者都能够在整个研究过程中保持有目的的控制，并且他们的在线表现随着时间的推移而提高。这项研究的结果表明，SCI 参与者可以有目的地操作自定进度的 BCI 步行模拟器来完成以目标为导向的步行任务。所提出的 BCI 系统的操作需要短期培训，直观且对参与者之间和日常神经生理学变化具有鲁棒性。这些发现表明，用于 SCI 后步态康复或恢复的 BCI 控制下肢假肢在未来可能是可行的。
Spinal cord injury (SCI) can leave the affected individuals with paraparesis or paraplegia, thus rendering them unable to ambulate. Since there are currently no restorative treatments for this population, novel approaches such as brain-controlled prostheses have been sought. Our recent studies show that a brain-computer interface (BCI) can be used to control ambulation within a virtual reality environment (VRE), suggesting that a BCI-controlled lower extremity prosthesis for ambulation may be feasible. However, the operability of our BCI has not yet been tested in a SCI population. Five participants with paraplegia or tetraplegia due to SCI underwent a 10-min training session in which they alternated between kinesthetic motor imagery (KMI) of idling and walking while their electroencephalogram (EEG) were recorded. Participants then performed a goal-oriented online task, where they utilized KMI to control the linear ambulation of an avatar while making 10 sequential stops at designated points within the VRE. Multiple online trials were performed in a single day, and this procedure was repeated across 5 experimental days. Classification accuracy of idling and walking was estimated offline and ranged from 60.5% (p = 0.0176) to 92.3% (p = 1.36×10−20) across participants and days. Offline analysis revealed that the activation of mid-frontal areas mostly in the μ and low β bands was the most consistent feature for differentiating between idling and walking KMI. In the online task, participants achieved an average performance of 7.4±2.3 successful stops in 273±51 sec. These performances were purposeful, i.e. significantly different from the random walk Monte Carlo simulations (p<0.01), and all but one participant achieved purposeful control within the first day of the experiments. Finally, all participants were able to maintain purposeful control throughout the study, and their online performances improved over time. The results of this study demonstrate that SCI participants can purposefully operate a self-paced BCI walking simulator to complete a goal-oriented ambulation task. The operation of the proposed BCI system requires short training, is intuitive, and robust against participant-to-participant and day-to-day neurophysiological variations. These findings indicate that BCI-controlled lower extremity prostheses for gait rehabilitation or restoration after SCI may be feasible in the future.
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中风后运动恢复的神经相关性：纵向功能磁共振成像研究。
DOI：
10.1093/brain/awg245
发表时间：
2003-11
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Ward NS;Brown MM;Thompson AJ;Frackowiak RS
通讯作者：
Frackowiak RS
影响因子：
4.2
作者：
Page SJ;Szaflarski JP;Eliassen JC;Pan H;Cramer SC
通讯作者：
Cramer SC
影响因子：
4
作者：
Zehnder, Y;Lüthi, M;Lippuner, K
通讯作者：
Lippuner, K
影响因子：
14.5
作者：
Cramer, SC;Lastra, L;Cohen, MJ
通讯作者：
Cohen, MJ
影响因子：
8
作者：
Das, Koel;Nenadic, Zoran
通讯作者：
Nenadic, Zoran