Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration.
Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration.
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DOI：
10.1111/j.1749-6632.2009.05134.x
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发表时间：
2010-01
影响因子：
5.2
通讯作者：
Cantrell D
中科院分区：
文献类型：
--
作者：
Finlay D;Cantrell D
磷脂酰肌醇(3，4，5)三磷酸(PI(3，4，5)P3)信号通路的既定作用是调节细胞代谢。最近发现，PI(3，4，5)P3信号通过mTOR和FOXO转录因子也通过决定T淋巴细胞表达的黏附和趋化因子受体来控制淋巴细胞的运输。在静止的T细胞中，非磷酸化的活性FOXOS维持KLF2的表达，KLF2是一种转录因子，调节趋化因子受体CCR7和S1P1以及黏附受体CD62L的表达，这两种受体共同控制T细胞向次级淋巴组织的迁移。PI(3，4，5)P3介导蛋白激酶B的激活，使Foxos磷酸化并失活，从而终止KLF2及其靶基因的表达。淋巴细胞的正确定位对有效的免疫应答至关重要，而PI3K和mTOR调节趋化因子受体和黏附分子表达的能力使这些信号分子处于控制淋巴细胞运输的分子机制的核心。
The established role for Phosphatidylinositol (3,4,5) triphosphate (PI(3,4,5)P3) signalling pathways is to regulate cell metabolism. More recently it has emerged that PI(3,4,5)P3 signalling via mTOR and Foxo transcription factors also controls lymphocyte trafficking by determining the repertoire of adhesion and chemokine receptors expressed by T lymphocytes. In quiescent T cells, non-phosphorylated active Foxos maintain expression of KLF2, a transcription factor that regulates expression of the chemokine receptors CCR7 and S1P1and the adhesion receptor CD62L that together control T cell transmigration into secondary lymphoid tissues. PI(3,4,5)P3 mediated activation of Protein Kinase B phosphorylates and inactivates Foxos thereby terminating expression of KLF2 and its target genes. The correct localization of lymphocytes is essential for effective immune responses and the ability of PI3K and mTOR to regulate expression of chemokine receptor and adhesion molecules puts these signaling molecules at the core of the molecular mechanisms that control lymphocyte trafficking.
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DOI：
10.1084/jem.20042020
发表时间：
2005-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.3
作者：
Díaz-Rodríguez, E;Montero, JC;Pandiella, A
通讯作者：
Pandiella, A
影响因子：
30.5
作者：
Costello, PS;Gallagher, M;Cantrell, DA
通讯作者：
Cantrell, DA
影响因子：
4.1
作者：
Currie, RA;Walker, KS;Lucocq, J
通讯作者：
Lucocq, J
影响因子：
64.8
作者：
Carlson, Corey M.;Endrizzi, Bart T.;Jameson, Stephen C.
通讯作者：
Jameson, Stephen C.