Adrenaline inhibits macrophage nitric oxide production through β1 and β2 adrenergic receptors
Adrenaline inhibits macrophage nitric oxide production through β1 and β2 adrenergic receptors
复制标题
肾上腺素通过 β1 和 β2 肾上腺素能受体抑制巨噬细胞一氧化氮的产生
作者：
L. Sigola;& R. B. Zinyama
本研究旨在探讨急性应激激素肾上腺素对巨噬细胞一氧化氮(NO)产生的影响。小鼠腹膜巨噬细胞在没有或有肾上腺素存在的情况下，用脂多糖(LPS)进行体外刺激。肾上腺素以剂量依赖的方式抑制内毒素诱导的亚硝酸盐反应。肾上腺素对NO产生的抑制作用是通过β1和β2肾上腺素能受体介导的，因为异丙肾上腺素(非选择性β1和β2激动剂)、多巴酚丁胺和沙丁胺醇(分别是选择性β1和β2激动剂)对NO的作用相似。此外，肾上腺素对NO的抑制作用可被非特异性β阻滞剂心得安和特异性β1抑制剂阿替洛尔所阻断。与β受体激活相反，α肾上腺素能激动剂苯肾上腺素对内毒素NO反应无影响，α受体拮抗剂酚妥拉明也不能改善肾上腺素的抑制作用。
This study was conducted to investigate the role of the acute stress hormone adrenaline on macrophage nitric oxide (NO) production. Murine peritoneal macrophages were stimulated in vitro with lipopolysaccharide (LPS) in the absence or presence of adrenaline. Adrenaline inhibited the LPS‐induced nitrite response in a dose‐dependent manner. The suppressive effect of adrenaline on NO production was mediated via β1 and β2 adrenergic receptors since isoprenaline (a non‐selective β1 and β2 agonist), dobutamine and salbutamol (selective β1 and β2 agonists, respectively) had similar effects on the NO response. In addition, the inhibitory effect of adrenaline on NO was abrogated by both propranolol (a non‐specific β blocker) and atenolol (a specific β1 inhibitor). In contrast to β receptor activation, the α adrenergic agonist phenylephrine had no effect on the LPS NO response, and furthermore, phentolamine (an α receptor antagonist) did not ameliorate adrenaline’s inhibitory action.
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
去甲肾上腺素通过蛋白激酶 A 依赖的细胞因子产生作用加速 HIV 复制。
DOI：
--
发表时间：
1998
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cole,SW;Korin,YD;Fahey,JL;Zack,JA
通讯作者：
Zack,JA
地塞米松对大鼠肺中 β2-肾上腺素能受体及其 mRNA 的调节。
影响因子：
1.7
作者：
McGraw,DW;Chai,SE;Hiller,FC;Cornett,LE
通讯作者：
Cornett,LE