Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice
Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice
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慢性阿卡波糖治疗可减轻 SAMP8 小鼠与年龄相关的行为和生化变化
DOI：
10.1016/j.bbr.2015.01.052
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发表时间：
2015-05
影响因子：
2.7
通讯作者：
Wei Zhao-Jun
中科院分区：
文献类型：
--
作者：
Tong Jing-Jing;Chen Gui-Hai;Wang Fang;Li Xue-Wei;Cao Lei;Sui Xu;Tao Fei;Yan Wen-Wen;Wei Zhao-Jun
维持胰岛素/胰岛素样生长因子1（IGF-1）信号传导和/或葡萄糖代谢的稳态的施用可以逆转脑老化。在本研究中，我们研究了阿卡波糖，α-葡萄糖苷酶抑制剂，对年龄相关的行为和生化变化的影响。SAMP 8小鼠随机分为老年对照组和阿卡波糖治疗组。阿卡波糖组小鼠从3至9月龄口服阿卡波糖（20 mg/kg/d，溶于饮用水），同时加入一组新的3月龄小鼠作为年轻对照。结果显示，老年对照组感觉运动能力、旷场焦虑、空间和非空间记忆能力下降，血清胰岛素水平降低，海马层IGF-1受体和突触结合蛋白1（Syt 1）水平升高，胰岛素受体、脑源性神经营养因子（BDNF）和突触融合蛋白1（Stx 1）水平降低。与年龄相关的行为缺陷与血清学和组织化学数据。长期阿卡波糖治疗缓解了这些年龄相关的变化，特别是在学习和记忆能力方面。阿卡波糖对年龄相关行为障碍的保护作用可能与胰岛素系统和BDNF，IGF-1 R以及突触前蛋白Syt 1和Stx 1水平的变化有关。总之，阿卡波糖的长期治疗改善了老年SAMP 8小鼠的行为缺陷和生化变化，并促进了成功的衰老。这项研究提供了深入了解阿卡波糖治疗脑老化的潜力。
The administration of maintaining the homeostasis of insulin/insulin-like growth factor 1 (IGF-1) signaling and/or glucose metabolism may reverse brain aging. In the present study, we investigated the effect of acarbose, an inhibitor of α-glucosidase, on age-related behavioral and biochemical changes. The SAMP8 mice were randomly divided into old control group and acarbose-treatment group. The mice in the acarbose group were administered acarbose (20 mg/kg/d, dissolved in drinking water) orally from 3 to 9 months of age when a new group of 3-month-old mice was added as young controls. The results showed that the aged controls exhibited declines in sensorimotor ability, open field anxiety, spatial and non-spatial memory abilities, decreased serum insulin levels, increased IGF-1 receptor and synaptotagmin 1 (Syt1) levels and decreased insulin receptor, brain-derived neurotrophic factor (BDNF) and syntaxin 1 (Stx1) levels in the hippocampal layers. The age-related behavioral deficits correlated with the serological and histochemical data. Chronic acarbose treatment relieved these age-related changes, especially with respect to learning and memory abilities. This protective effect of acarbose on age-related behavioral impairments might be related to changes in the insulin system and the levels of BDNF, IGF-1R, and the pre-synaptic proteins Syt1 and Stx1. In conclusion, long-term treatment with acarbose ameliorated the behavioral deficits and biochemical changes in old SAMP8 mice and promoted successful aging. This study provides insight into the potential of acarbose for the treatment of brain aging.
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影响因子：
15.1
作者：
Wang X;Zheng W;Xie JW;Wang T;Wang SL;Teng WP;Wang ZY
通讯作者：
Wang ZY
影响因子：
158.5
作者：
Nissen, Steven E.;Wolski, Kathy
通讯作者：
Wolski, Kathy
影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
影响因子：
3
作者：
J. Morley;S. Farr;Vijaya B. Kumar;W. Banks
通讯作者：
J. Morley;S. Farr;Vijaya B. Kumar;W. Banks
影响因子：
3.7
作者：
Kuhla A;Lange S;Holzmann C;Maass F;Petersen J;Vollmar B;Wree A
通讯作者：
Wree A