Lifelong caloric restriction increases working memory in mice.
Lifelong caloric restriction increases working memory in mice.
复制标题
DOI：
10.1371/journal.pone.0068778
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wree A
中科院分区：
文献类型：
--
作者：
Kuhla A;Lange S;Holzmann C;Maass F;Petersen J;Vollmar B;Wree A
热量限制（CR）被认为对一般健康，长寿和正常发生的与年龄相关的认知能力下降有积极影响。这个问题已经得到了很好的研究，但大多数研究调查了短期CR的影响。在此，对4周龄的雌性小鼠进行热量限制喂养4周、20周，特别是74周。CR小鼠接受其随意（AL）喂养的同窝仔所吃食物的60%，并对所有年龄匹配的组进行行为分析。用旋转/加速杆测试的运动协调性随年龄增长而下降，但不受CR时间的影响。与此相反，年龄相关的自发运动活动和焦虑障碍，无论是通过开放领域和高架十字迷宫测试进行评估，发现加重了终身CR。Morris水迷宫测试结果显示，AL小鼠的工作记忆能力随年龄增长而下降，而终身CR喂养可提高AL小鼠的认知能力，并在74周CR喂养后显著提高其空间记忆能力。然而，66周龄小鼠的迟发性CR喂养并没有改善工作记忆。因此，终身CR似乎是必要的，以提高工作记忆。
Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL) fed littermates, and all age-matched groups were behaviorally analyzed. The motor coordination, which was tested by rotarod/accelerod, decreased age-related, but was not influenced by the different periods of CR. In contrast, the age-related impairment of spontaneous locomotor activity and anxiety, both being evaluated by open field and by elevated plus maze test, was found aggravated by a lifelong CR. Measurement of cognitive performance with morris water maze showed that the working memory decreased age-related in AL mice, while a lifelong CR caused a better cognitive performance and resulted in a significantly better spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR seems to be necessary to improve working memory.
登录
查看更多内容
影响因子：
5.3
作者：
Adams, Michelle M.;Shi, Lei;Brunso-Bechtold, Judy K.
通讯作者：
Brunso-Bechtold, Judy K.
影响因子：
3.1
作者：
Bergado, Jorge A.;Almaguer, William
通讯作者：
Almaguer, William
影响因子：
1.7
作者：
Hashimoto, T;Watanabe, S
通讯作者：
Watanabe, S
影响因子：
2.2
作者：
Deng, L.;Wu, Z. -N.;Han, P. -Z.
通讯作者：
Han, P. -Z.
影响因子：
4.8
作者：
Forster, MJ;Morris, P;Sohal, RS
通讯作者：
Sohal, RS