Cardiovascular magnetic resonance imaging in children after recovery from symptomatic COVID-19 or MIS-C: a prospective study.
Cardiovascular magnetic resonance imaging in children after recovery from symptomatic COVID-19 or MIS-C: a prospective study.
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DOI：
10.1186/s12968-021-00786-5
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发表时间：
2021-07-01
期刊：
影响因子：
--
通讯作者：
Robinson JD
中科院分区：
文献类型：
--
作者：
Webster G;Patel AB;Carr MR;Rigsby CK;Rychlik K;Rowley AH;Robinson JD
心脏评估，包括心血管磁共振（CMR）成像和生物标志物的结果，需要在儿童感染SARS-CoV-2后的中期恢复。康复后1-3个月CMR异常的发生率在老年人中超过50%，在大学运动员中介于1%和15%之间。异常的心脏生物标志物在成年人中很常见，即使在恢复期间也是如此。我们在一个前瞻性招募的从COVID-19和儿童多系统炎症综合征（MIS-C）中康复的儿科队列中进行了CMR成像。我们获得了CMR数据和血清生物标志物。我们将这些结果与SARS-CoV-2大流行之前成像的年龄匹配的对照患者进行了比较。在17名儿童（13.9岁，均≤ 18岁）和29名年龄匹配的对照患者中进行了CMR，这些患者没有SARS-CoV-2感染。招募了有症状的COVID-19（11/17，65%）或MIS-C（6/17，35%）病例，并在诊断后平均2个月进行研究。所有COVID-19患者在感染期间都有发烧（73%），呕吐/腹泻（64%）或呼吸困难（55%）的症状。左心室和右心室射血分数在病例组和对照组之间无法区分（分别为p = 0.66和0.70）。平均自体整体T1、整体T2值和节段性T2最大值与对照患者也无统计学差异（均为p ≥ 0.06）。所有儿童的NT-proBNP和肌钙蛋白水平均正常。在SARS-CoV-2感染后前瞻性招募的儿童在中期恢复期间具有正常的CMR和心脏生物标志物评估。试验注册不适用。
Cardiac evaluations, including cardiovascular magnetic resonance (CMR) imaging and biomarker results, are needed in children during mid-term recovery after infection with SARS-CoV-2. The incidence of CMR abnormalities 1–3 months after recovery is over 50% in older adults and has ranged between 1 and 15% in college athletes. Abnormal cardiac biomarkers are common in adults, even during recovery. We performed CMR imaging in a prospectively-recruited pediatric cohort recovered from COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We obtained CMR data and serum biomarkers. We compared these results to age-matched control patients, imaged prior to the SARS-CoV-2 pandemic. CMR was performed in 17 children (13.9 years, all ≤ 18 years) and 29 age-matched control patients without SARS-CoV-2 infection. Cases were recruited with symptomatic COVID-19 (11/17, 65%) or MIS-C (6/17, 35%) and studied an average of 2 months after diagnosis. All COVID-19 patients had been symptomatic with fever (73%), vomiting/diarrhea (64%), or breathing difficulty (55%) during infection. Left ventricular and right ventricular ejection fractions were indistinguishable between cases and controls (p = 0.66 and 0.70, respectively). Mean native global T1, global T2 values and segmental T2 maximum values were also not statistically different from control patients (p ≥ 0.06 for each). NT-proBNP and troponin levels were normal in all children. Children prospectively recruited following SARS-CoV-2 infection had normal CMR and cardiac biomarker evaluations during mid-term recovery. Trial Registration Not applicable.
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影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
24
作者：
Puntmann, Valentina O.;Carerj, M. Ludovica;Nagel, Eike
通讯作者：
Nagel, Eike
影响因子：
33.9
作者：
Godfred-Cato, Shana;Bryant, Bobbi;Belay, Ermias
通讯作者：
Belay, Ermias
DOI：
10.1186/s12968-017-0387-x
发表时间：
2017-09-21
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Baeßler B;Treutlein M;Schaarschmidt F;Stehning C;Schnackenburg B;Michels G;Maintz D;Bunck AC
通讯作者：
Bunck AC
影响因子：
6.4
作者：
Giri, Shivraman;Chung, Yiu-Cho;Simonetti, Orlando P.
通讯作者：
Simonetti, Orlando P.